SubjectsSubjects(version: 901)
Course, academic year 2021/2022
Structure and Reactivity - M342002
Title: Struktura a reaktivita
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2019
Semester: summer
Points: summer s.:4
E-Credits: summer s.:4
Examination process: summer s.:
Hours per week, examination: summer s.:2/1 C+Ex [hours/week]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Parkan Kamil Ing. Ph.D.
Interchangeability : N342003
Annotation -
Last update: Kubová Petra Ing. (19.12.2017)
The subject is aimed at understanding basic principles and mechanisms in modern organic chemistry. Attention is given primarily to the structure of organic compounds and their reactivity which is a prerequisite for a deeper understanding of organic chemistry.
Aim of the course -
Last update: Parkan Kamil Ing. Ph.D. (27.02.2018)

Students will be able to:

Understand the basics of molecular structure (AO, MO) and structure of organic compounds (isomers)

Assess reactivity of organic compounds (thermodynamics, kinetics)

Depict reaction mechanisms of principle organic reactions (nucleophilic substitution, addition, elimination, …)

Literature -
Last update: Kubová Petra Ing. (19.12.2017)

R: Mark G. Moloney: Structure and Reactivity in Organic Chemisty, Wiley-Blackwell, 2008, 978-1405114516

A: McMurry J.: Organic chemistry, 8th Ed., Brooks/Cole, Cengage Learning, 2012, 9780840054449

Learning resources -
Last update: Kubová Petra Ing. (19.12.2017)

Lecture notes

Syllabus -
Last update: Parkan Kamil Ing. Ph.D. (26.08.2020)

1. Valency (structure, covalent bond)

2. Structure (configuration, conformation)

3. Reactivity (thermodynamics, kinetics, …)

4. Intermediates (carbocations, carbanions, radicals, carbenes, benzynes, ketenes)

5. Acids and bases (Lowry-Brønsted theory)

6. Nucleophilic substitution (SN1 reaction, SN2 reaction, synthetic applications)

7. Addition reactions (AE, AN, addition of ketenes, synthetic applications)

8. Elimination reactions (elimination, oxidation processes, …)

9. Aromatic substitution (aromaticity, reactions)

10. Stepwise addition and elimination reactions (addition-elimination reaction, metathesis, …)

11. Radical reactions (radical generation, subsequent reactions)

12. Coupling reactions (Pd-catalyzed reactions, reactions catalyzed by other elements)

13. Pericyclic reactions (molecular orbitals, pericyclic reactions, synthetic applications)

14. Aldol reaction and condensation, Claisen reaction, conjugate addition reaction

15. Types of non-covalent bonds (hydrogen bond in bioorganic molecules, …)

Registration requirements -
Last update: Parkan Kamil Ing. Ph.D. (27.02.2018)

Organic chemistry I, or Organic chemistry A and B

Course completion requirements
Last update: Parkan Kamil Ing. Ph.D. (27.02.2018)

Napsání započtového testu, zkouškového testu a ústní zkouška.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 1 28
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