SubjectsSubjects(version: 901)
Course, academic year 2021/2022
  
Labelled Compounds - M342007
Title: Izotopově značené sloučeniny
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2020
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Havlíček Libor doc. Ing. CSc.
Interchangeability : N342012
Annotation -
Last update: Kubová Petra Ing. (19.12.2017)
The course covers the potential of application of isotopically (using stable as well as radioactive isotope) labeled compounds in chemistry, biology and medicine with special aspects of this discipline (synthesis in ng to mg scale, nomenclature, radiolysis, isotopic effect, hygiene of ionizing radiation)
Aim of the course -
Last update: Kubová Petra Ing. (19.12.2017)

Students will be able to:

Give the most important applications of labeled compounds in natural sciences research, in drug development, and in practical medicine

Name syntheses of these compounds (with emphasis on both relations and differences from usual synthetic chemistry of organic compounds)

Formulate measures due to radiation hygiene

Literature -
Last update: Kubová Petra Ing. (19.12.2017)

R: Navrátil O., Hála J., Kopunec R., Macášek F., Mikulaj V., Lešetický L. Nuclear chemistry, Academia, Praha 1992.

A: Evans E. A., Oldham K. G.: Radiochemicals in Biomedicinal Research , John Wiley and Sons

A: Evans E. A., Tritium and its compounds, Butterworths, 2. ed.

A: Murray A., Williams D.L.: Organ. Syntheses with Isotopes

A: Donald G.: Syntheses with Stable Isotopes

A: Thomas A. F.: Deuterium Labeling in Organic Chemistry

Learning resources -
Last update: Kubová Petra Ing. (19.12.2017)

Lecture notes with formulae and reaction schemes

Syllabus -
Last update: Kubová Petra Ing. (19.12.2017)

1. Definitions of concepts and quantities in the field of labeled compounds (LC), historical overview, importance of LC, intersections with other disciplines, literature

2. Types of radioactive transformations, kinetics of radioactive transformations, interaction of ionizing radiation (IoR) with matter, other physical principles in LC

3. Dosimetry of IoR (detectors: ionizing, scintillating, integral dosimetry methods)

4. Principles of IoR hygiene. Definition of quantities, basic knowledge of IoR effects on molecule, cell, and organism level, hygiene findings, IoR effects

5. Protection against IoR, LNT basis, ALARA access, lesson from serious nuclear disasters

6. Radio iodine, designation for immune chemical determinations (RIA, IRMA, REA, RRA, FPIA, …)

7. Specialties of LC chemistry (isotopic effect, nomenclature of LC, LC stability, specialties resulting from micro scale synthesis in mg to ng)

8. Overview of application of LC, equivalency of chemical bonds, tautomery, reaction mechanisms, biochemical pathways, internal enzyme transfer, metabolic turns, receptor study, drug development)

9. Hydrogen isotopes labeled compounds. Properties of [3H]-compounds, their synthesis

10. 14C nuclide labeled compounds, 32P or 33P nuclide labeled compounds

11. Labeling with stable nuclides (2H, 13C). Application areas, requirements, synthesis

12. Nuclear medicine - diagnostics (functional diagnostics, "ideal emitter", pure gamma, positron tomography, PET, "shorts", therapy

13. Labeled compounds analysis

14. Chemistry of LC of selected structures (peptides, …)

Registration requirements -
Last update: Kubová Petra Ing. (19.12.2017)

Organic chemistry I

Course completion requirements - Czech
Last update: MORAVCOJ (27.02.2018)

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