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Methods of Pharmaceuticals Analysis - M402046
Title: Metody analýzy léčiv
Guaranteed by: Department of Analytical Chemistry (402)
Faculty: Faculty of Chemical Engineering
Actual: from 2019
Semester: winter
Points: winter s.:5
E-Credits: winter s.:5
Examination process: winter s.:
Hours per week, examination: winter s.:3/0, Ex [HT]
Capacity: 26 / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Master's
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Sýkora David doc. RNDr. Dr.
Interchangeability : N402055
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (11.01.2018)
Principles and applications of frequently used analytical methods in pharmaceutical laboratories are discussed with focus on separation techniques and other relevant methods.
Aim of the course -
Last update: Kubová Petra Ing. (11.01.2018)

Students will obtain knowledge on many important analytical techniques applied in pharma laboratories. The most frequently used techniques will be covered in detail.

Literature -
Last update: Kubová Petra Ing. (11.01.2018)

R: High Performance Capillary Electrophoresis - firemní příručka, D.N. Heiger, Hewlett-Packard, 1992.

R: Basic Gas Chromatography - kniha, H.M. McNair and J.M. Miller, Wiley, 2009, ISBN: 978-0-470-43954-8.

R: Practical High-Performance Liquid Chromatography - kniha, V.R. Meyer, Wiley, 2010, ISBN:978-0-470-68218-0.

R: Introduction to Mass Spectrometry - kniha, J.T. Watson and O.D. Sparkman, Wiley, 2007, ISBN: 978-0-470-51634-8.

Learning resources -
Last update: Kubová Petra Ing. (11.01.2018)

http://onlinelibrary.wiley.com/book/10.1002/9780470688427
Syllabus -
Last update: Kubová Petra Ing. (11.01.2018)

1. Introduction to the separation methods, their basic characterization.

2. Capillary electrophoresis and electrochromatography.

3. Gas Chromatography (GC). Principles, injection techniques, columns, detectors.

4. Liquid chromatography (LC). Principles, separation modes, instrumentation, sorbents and columns, detectors.

5. Supercritical fluid chromatography. Principles and instrumentation.

6. Simulated Moving Bed technique. Description of the method, applications.

7. Solid phase extraction. Principles and applications.

8. Mass spectrometry (MS). Ionization techniques, analyzers, detectors, GC-MS a LC-MS.

9. Methods of drug analysis in solid phase.

10. Polymorphism of API and analytical methods used for their detection.

11. Dissolution and adsorption of drugs.

12. Spectroscopic techniques of drug analysis - 1.

13. Spectroscopic techniques of drug analysis - 2.

14. Registration of new pharmaceuticals.

Entry requirements -
Last update: Sýkora David doc. RNDr. Dr. (12.02.2018)

The students need to know analytical chemistry on the level of Analytical chemistry I.

Registration requirements -
Last update: Sýkora David doc. RNDr. Dr. (12.02.2018)

The students need to know analytical chemistry on the level of Analytical chemistry I.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.5 14
Účast na přednáškách 1.5 42
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0.5 14
Příprava na zkoušku a její absolvování 2.5 70
5 / 5 140 / 140
 
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