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Principles and applications of frequently used analytical methods in pharmaceutical laboratories are discussed with focus on separation techniques and other relevant methods.
Last update: Kubová Petra (11.01.2018)
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R: High Performance Capillary Electrophoresis - firemní příručka, D.N. Heiger, Hewlett-Packard, 1992. R: Basic Gas Chromatography - kniha, H.M. McNair and J.M. Miller, Wiley, 2009, ISBN: 978-0-470-43954-8. R: Practical High-Performance Liquid Chromatography - kniha, V.R. Meyer, Wiley, 2010, ISBN:978-0-470-68218-0. R: Introduction to Mass Spectrometry - kniha, J.T. Watson and O.D. Sparkman, Wiley, 2007, ISBN: 978-0-470-51634-8. Last update: Kubová Petra (11.01.2018)
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1. Introduction to the separation methods, their basic characterization. 2. Capillary electrophoresis and electrochromatography. 3. Gas Chromatography (GC). Principles, injection techniques, columns, detectors. 4. Liquid chromatography (LC). Principles, separation modes, instrumentation, sorbents and columns, detectors. 5. Supercritical fluid chromatography. Principles and instrumentation. 6. Simulated Moving Bed technique. Description of the method, applications. 7. Solid phase extraction. Principles and applications. 8. Mass spectrometry (MS). Ionization techniques, analyzers, detectors, GC-MS a LC-MS. 9. Methods of drug analysis in solid phase. 10. Polymorphism of API and analytical methods used for their detection. 11. Dissolution and adsorption of drugs. 12. Spectroscopic techniques of drug analysis - 1. 13. Spectroscopic techniques of drug analysis - 2. 14. Registration of new pharmaceuticals. Last update: Kubová Petra (11.01.2018)
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http://onlinelibrary.wiley.com/book/10.1002/9780470688427 Last update: Kubová Petra (11.01.2018)
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Students will obtain knowledge on many important analytical techniques applied in pharma laboratories. The most frequently used techniques will be covered in detail.
Last update: Kubová Petra (11.01.2018)
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The students need to know analytical chemistry on the level of Analytical chemistry I. Last update: Sýkora David (12.02.2018)
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The students need to know analytical chemistry on the level of Analytical chemistry I. Last update: Sýkora David (12.02.2018)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.5 | 14 | ||
Účast na přednáškách | 1.5 | 42 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 2.5 | 70 | ||
5 / 5 | 140 / 140 |