SubjectsSubjects(version: 941)
Course, academic year 2019/2020
Bioengineering Methods - M409010
Title: Bioinženýrské metody
Guaranteed by: Department of Chemical Engineering (409)
Faculty: Faculty of Chemical Engineering
Actual: from 2019 to 2019
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Schreiber Igor prof. Ing. CSc.
Přibyl Michal prof. Ing. Ph.D.
Hasal Pavel prof. Ing. CSc.
Interchangeability : AM409010, N409057
Is interchangeable with: AM409010
Examination dates   Schedule   
Annotation -
Last update: Hladíková Jana (16.01.2018)
The course is building on the basic knowledge of chemical engineering by the student and develops applications in bioengineering. Basic approaches including mass and energy balances, transport processes and reaction kinetics are synthesized to provide quantitative description of processes used in bioengineering. Special attention is given to reaction-transport processes in enzyme reactors and reactors with living cultures of microorganisms.
Aim of the course -
Last update: Hladíková Jana (16.01.2018)

Students will be able to:

apply quantitative approaches of chemical engineering to biosystems

design basic types of enzyme reactors and bioreactors

design suitable unit operations for modification of inlets and outles from the bioreactor

Literature -
Last update: Schreiber Igor prof. Ing. CSc. (12.11.2018)

R: Shuler M. L. , Kargi F., DeLisa M., Bioprocess Engineering: Basic Concepts, 3rd Edition, Prentice Hall 2017, ISBN-13: 9780132901451

A: Doran P., Bioprocess Engineering Principles - 2nd Edition, Academic press 2012, ISBN: 9780122208515, 9780080917702

A: Villadsen J., Lee S.Y., Nielsen J., Stephanopoulos G. (eds.), Fundamental Bioengineering, Wiley-Blackwell, 2016, ISBN: 978-3527336746.

Learning resources -
Last update: Hladíková Jana (16.01.2018)

lecture notes available at

Syllabus -
Last update: Hladíková Jana (16.01.2018)

1. Enzyme catalysis, thermodynamics of enzyme reactions, limitin cases

2. Enzyme reactors, mathematical models and their analysis

3. Immobilized enzymes, effects of mass transport

4. Effectiveness factor, Damköhler number, analysis of heterogeneous enz. systems

5. Microbial growth, stoichiometry of growth, product formation

6. Growth in batch systems

7. Growth in continual systems

8. Structured vs unstructured models of growth

9. Construction and operation of some fermentor types

10. Stirring and aeration

11. Mixed microbial cultures and their interaction

12. Chemostat dynamics with mixed cultures

13. Operating conditions, scale-up

14. Metabolic engineering, metabolic networks

Registration requirements -
Last update: Hladíková Jana (16.01.2018)

Unit operations of chemical engineering I and II

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 0.5 14
4 / 4 112 / 112
Coursework assessment
Form Significance
Continuous assessment of study performance and course -credit tests 50
Oral examination 50