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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
Students will gain knowledge about: internal structure of pharmaceutical substances (crystalline and molecular) they will learn to orient themselves in the processes of crystallization and dissolution of pharmaceutical substances will be able to apply and categorize the phenomenon of polymorphism in pharmacies to orient among solid forms of pharmaceutical substances (anhydrate, hydrates, salts, co-crystals and amorphous) to estimate possible degradation processes that occur in solid pharmaceutical substances |
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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
R:Hilfiker R.(Ed.), Polymorphism in the Pharmaceutical Industry, Wiley-VCH Verlag, Weinheim, Germany, 2006, 9783527311460 |
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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
lectures for the course: https://uchpel.vscht.cz/studium/studijni_materialy |
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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
1. API Selection Criteria for Solid Drug Forms 2. Crystal structure 3. Molecular Crystal 4. Crystallization 5. Solubility and dissolution 6. Shape and particle size 7. Polymorphism 7. Anhydrates, hydrates, salts, co-crystals 8. Amorphous and semicrystalline forms 9. Physical (polymorphic) transformations, examples 10.Chemical degradation in solid phase 11.Oxidation, hydrolysis, dehydration, dehalogenation, decarboxylation, deamidation, denitrogenation 12.Fotodegradation 13.Polymerization, cyclization, epimerization, isomerization 14.Hygroscopicity |
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Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)
Organic chemistry I, II
Fundamentals of Pharmacology
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.5 | 14 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na zkoušku a její absolvování | 1.5 | 42 | ||
3 / 3 | 84 / 84 |
Coursework assessment | |
Form | Significance |
Oral examination | 100 |