SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Transition Metals in Organic Synthesis - N110014
Title: Přechodné kovy v organické syntéze
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2017
Semester: winter
Points: winter s.:6
E-Credits: winter s.:6
Examination process: winter s.:
Hours per week, examination: winter s.:3/1 C+Ex [hours/week]
Capacity: 15 / 15 (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Additional information: http://Předmět je vyučován jen v ZS
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Dvořák Dalimil prof. Ing. CSc.
Annotation -
Last update: Dvořák Dalimil prof. Ing. CSc. (28.04.2005)
Reactions based on the chemistry of transition metals play an important role both in the chemical industry and in the organic synthesis. This course is divided into two parts. In the first part the students familiarize themselves with basic principles of the chemistry of transition metals, with the reactions in coordination sphere and with chemical properties of common ligands. The second part deals with an application of this chemistry in some important industrial processes and especially in the organic synthesis.
Aim of the course -
Last update: Cibulka Radek prof. Ing. Ph.D. (19.08.2013)

Students will be able to:

distinguish basic types of reactions which occur in the coordination sphere of transition metals

understand the mechanisms of transition metals catalyzed reactions which are used in organic synthesis

propose synthesis of organic compounds using chemistry of transition metals

Literature -
Last update: Dvořák Dalimil prof. Ing. CSc. (23.07.2013)

R:L. S. Hegedus: Transition Metals in the Synthesis of Complex Organic Molecules (University Science Books, Sausalito, California, 1999), 1891389041

A:Skripta: D. Dvořák: Chemie organokovových sloučenin přechodných kovů (VŠCHT 1993), 80-7080-209-X

Learning resources -
Last update: Dvořák Dalimil prof. Ing. CSc. (23.07.2013)

Dalimil Dvořák: Chemie organokovových sloučenin přechodných kovů:

http://uoch.vscht.cz/cz/download/metalika.pdf

Syllabus -
Last update: Dvořák Dalimil prof. Ing. CSc. (28.04.2005)

1. Formalism (oxidation state, d-electron configuration, 18-electron rule).

2. Basic types of ligands (s-complexes).

3. Basic types of ligands (p-complexes).

4. Reactions in coordination sphere of transition metals (ligand substitution, oxidative addition, reductive elimination, insertion, transmetallation).

5. Nucleophilic attack on ligands coordinated to transition metals.

6. Electrophilic attack on ligands coordinated to transition metals.

7. Homogeneous catalytic reactions (hydrogenation, hydrosilation, hydrocyanation, alkene and alkyne polymerisation, carbonylation reactions).

8. Synthetic applications of transition metal hydrides, organocuprates.

9. Synthetic applications of complexes from insertion of alkenes and alkynes.

10. Synthetic applications of complexes from oxidative addition followed with insertion of alkene, alkyne and carbon monoxide (cross coupling, Heck reaction).

11. Synthetic applications of transition metal carbonyl complexes.

12. Synthetic applications of transition metal carbene complexes (reactions of nucleophilic and electrophilic carbenes, alkene metathesis, metal-catalysed decomposition of diazo compounds).

13. Synthetic applications of h3-allyl transition metal complexes.

14. Synthetic applications of transition metal h6-arene complexes (Cr(CO)3 and FeCp+ complexes).

Registration requirements -
Last update: Dvořák Dalimil prof. Ing. CSc. (23.07.2013)

Organic synthesis, Mechanisms of organic reactions

Teaching methods
Activity Credits Hours
Účast na přednáškách 1,5 42
Příprava na zkoušku a její absolvování 4 112
Účast na seminářích 0,5 14
6 / 6 168 / 168
Coursework assessment
Form Significance
Continuous assessment of study performance and course -credit tests 50
Oral examination 50

 
VŠCHT Praha