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Last update: TAJ111 (03.12.2013)
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Last update: TAJ111 (29.07.2013)
Students will be able to:
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Last update: TAJ111 (29.07.2013)
R:Otová B., Mihalová R.: Základy biologie a genetiky člověka, Karolinum, Praha 2012, ISBN 978-80-246-2109-8 A:Otová B. a kolektiv: Lékařská biologie a genetika I. díl. Karolinum, Praha 2008, ISBN 978-80-246-1594-3 A:Kohoutová M. a kolektiv: Lékařská biologie a genetika II. díl. Karolinum, Praha 2012, ISBN 978-80-246-1873-9 A:Kočárek E.: Genetika. Scientia, Praha 2008, ISBN 978-80-869-6036-4 |
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Last update: TAJ111 (29.07.2013)
http://tresen.vscht.cz/kot/blog/studium/bakalarske/biologie-cloveka |
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Last update: TAJ111 (29.07.2013)
1. Prokaryote, Eukaryote. Eukaryotic cell; Cell cycle and its regulation; Cell signalization. Tissue; Organism. 2. J. G. Mendel and his laws of inheritance; Gene, Alleles, Genotype, Phenotype; Monogenic inheritance; Interaction of non-allelic genes; Multifactorial inheritance. 3. Molecular and biochemical reasons of inherited diseases; Prevention and treatment; Pedigree analysis; Pharmacogenetics. 4. Cytogenetics; Human karyotype; Chromosome number and structure; techniques of examination; Disorders of the autosomes and sex chromosomes; in vitro cultivation of cells. 5. Mitosis; Meiosis and its disturbances; Nondisjunction; Examples of syndromes; Gametogenesis. 6. Genetic linkage; crossing-over; genetic mapping (indirect and physical); Haplotype; Application of genetic linkage - Indirect DNA diagnostics. 7. Genetics of embryonic development; Sex differentiation and its disturbances; Apoptosis; Ontogenesis; Molecular aspects of Aging. 8. Molecular genetics; DNA structure and function; Replication; RNA (mRNA, tRNA, rRNA) - structure and function; Transcription and RNA processing; Ribosome; Genetic code; Translation. 9. Gene structure and function; Nucleic acid polymorphisms; Gene polymorphisms; SNP; Gene mutations - types and effects; Direct and indirect methods of DNA diagnostics. Mutagenic and teratogenic factors of environment. 10. Multifactorial inheritance; Heritability; Diseases; Prevention and treatment - life style, pharmacotherapy, nutrition. 11. Population; Castle-Hardy-Weinberg law; Factors affecting C-H-W equilibrium - mutations, selection; Genetic drift and gene flow. Consanguinity; Inbreeding; Evolution of human species - macro- and micro-evolution 12. Immunogenetics; Immunity - non-specific, specific; Antigenes; Antibodies; Blood groups - genetics and clinical importance; Haemolytic disease of the newborn; B and T lymphocytes; Function of immunocompetent cells; Cytokines; Immunoglobulin -structure and function; Histocompatibility - Major histocompatibility complex - HLA locus of man. 13. Transplantation; Transplantation antigenes; Transplantation principles; Haplotype; GVHR (transplantation of bone marrow); Immunotolerance; Immunodeficiency; Immunosuppression; Immunity and tumours. 14. Oncogenetics; Protooncogenes, tumour-suppressor genes, mutator genes; Benign and malignant tumours; Angiogenesis; Metastasis; Cancer families; Cytogenetic analysis of tumour cells; New methods of treatment according to genetic |
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Last update: TAJ111 (29.07.2013)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.5 | 14 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1 | 28 | ||
Příprava na zkoušku a její absolvování | 2 | 56 | ||
Účast na seminářích | 0.5 | 14 | ||
5 / 4 | 140 / 112 |
Coursework assessment | |
Form | Significance |
Regular attendance | 10 |
Examination test | 40 |
Oral examination | 50 |