SubjectsSubjects(version: 877)
Course, academic year 2020/2021
  
Biochemistry of Secondary Metabolites - N319011
Title: Biochemie sekundárních metabolitů
Guaranteed by: Department of Biotechnology (319)
Actual: from 2019
Semester: summer
Points: summer s.:4
E-Credits: summer s.:4
Examination process: summer s.:
Hours per week, examination: summer s.:2/1 C+Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
Is provided by: M319002
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Masák Jan prof. Ing. CSc.
Z//Is interchangeable with: M319002
Annotation -
Last update: TAJ319 (10.12.2013)
A number of secondary metabolites are among important biotech products used in medicine, food and chemical industry and in many other areas of human activity. Although metabolic pathways for the synthesis of these compounds are based on metabolites of the general (primary) metabolism, they are specific to particular groups of organisms and have different regulatory mechanisms. The lectures explain the general relationships between primary and secondary metabolism and evolution of metabolic pathways of secondary metabolism. After a survey of the individual groups of secondary metabolites, closer attention is paid to microbial and plant compounds such as antibiotics, cancerostatics, alkaloids, terpenic oils etc.. In detail are discussed its biosynthetic pathways, physico-chemical properties, biological activity, the mechanisms of interaction with other organisms and resistance to their effects. Part of the seminar is an individual work devoted to a selected group of secondary metabolites.
Aim of the course -
Last update: TAJ319 (10.12.2013)

Students will be able to:

characterize important groups or individual compounds produced by secondary metabolism;

describe the important metabolic pathways for the synthesis of secondary metabolites and their regulation;

propose application of the most important secondary metabolites;

recognize the risks associated with the mechanism and evolution of resistance to secondary metabolites such as used in medicine, food, etc.

Literature -
Last update: TAJ319 (30.08.2013)

R:Rehm,H.-J.,Reed G.: Biotechnology: Products of Secondary Metabolism, Vol 7, 2nd Ed, Wiley, Weinheim, 2008, 9783527620890

A:Cole,R.J.: Handbook of Secondary Fungal Metabolites, Elsevier, New York,2003, 978012179606

A:Crozier,A:Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet,Wiley, Oxford, 2006, 978145125093

Learning resources -
Last update: Masák Jan prof. Ing. CSc. (30.08.2013)

http://eso.vscht.cz/

Syllabus
Last update: Masák Jan prof. Ing. CSc. (30.08.2013)

1. Introduction - definitions of "secondary metabolism", "secondary metabolite"

2. Origin, evolution and genetic determination of secondary metabolism

3. Distribution and function of secondary metabolism in living organisms

4. List of important metabolic pathways of secondary metabolism and their regulation

5. Overview of the biological activities of secondary metabolites

6. Secondary metabolism in microorganisms

7. Antimicrobial compounds

8. Secondary metabolites with cancerostatic activity

9. Microbial toxins

10. Microbial alkaloids and growth modulators

11. Secondary metabolites produced by plants I

12. Secondary metabolites produced by plants II

13. Resistance mechanisms against the toxic effects of secondary metabolites

14. Current trends in research and application of secondary metabolites

Registration requirements -
Last update: Masák Jan prof. Ing. CSc. (30.08.2013)

Biochemistry, Microbiology, Organic chemistry

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1 28
Práce na individuálním projektu 1 28
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 0,5 14
4 / 4 112 / 112
Coursework assessment
Form Significance
Regular attendance 30
Defense of an individual project 30
Oral examination 40

 
VŠCHT Praha