Natural and Modified Polysaccharides in Pharmacy - N321022
Title: Přírodní a modifikované polysacharidy ve farmacii
Guaranteed by: Department of Carbohydrates and Cereals (321)
Actual: from 2017
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Čopíková Jana prof. Ing. CSc.
Sinica Andrej doc. Mgr. Ph.D.
Examination dates   
Annotation -
Last update: Čopíková Jana prof. Ing. CSc. (15.11.2012)
Polysaccharides are natural biopolymers that are widely used in pharmaceutical industry. Polysaccharides, their derivatives and oligomers do not have only complementary functions in drug forms, but also may be directly involved into the medicinal effects of pharmaceutical preparations. In the frame of subject course students will be introduced to structure and physical properties of medicinally important polysaccharides and their oligomers. Then the physical and chemical properties of polysaccharides, preparation of biologically active derivatives and oligosaccharides will be described. A substantial part of the course is devoted to applications and biological significance of polysaccharides in medicaments and other pharmaceutical preparations.
Aim of the course -
Last update: TAJ321 (18.12.2013)

Students will learn the structure, analysis, applications and benefits of polysaccharides in pharmacy.

Literature -
Last update: TAJ321 (03.10.2013)

R: Martínková Jiřina a kol.: Farmakologie, Grada, 2007, ISBN-13: 978-80-247-1356-4

R: Lüllmann Heinz, Mohr Klaus, Wehling Martin: Farmakologie a toxikologie, Grada, 2004, ISBN 80-247-0836-1

A: Dumitriu Severien: Polysaccharides in Medicinal Applications, Marcel Dekker, INC, 1996, ISBN 0-8247-9540-7

Learning resources -
Last update: Čopíková Jana prof. Ing. CSc. (26.09.2013)

Basic

Severian Dumitriu: Polysaccharides in Medicinal Applications, M. Dekker, 1996

R. H. Marchessault, François Ravenelle, Xiao Xia Zhu: Polysaccharides for drug delivery and pharmaceutical applications, American Chemical Society, 2006

Complementary

Journal: Carbohydrate Polymers

Syllabus -
Last update: Čopíková Jana prof. Ing. CSc. (15.11.2012)

1. Sources, function and metabolism of polysaccharides, their importance in Nature

2. Nomenclature of polysaccharides, chemical composition and major functional groups

3. Structural diversity and conformation of polysaccharides, their complexes with other molecules (proteins, polyphenols, macrocycles)

4. Procedures for isolation of polysaccharides from natural raw materials, purification and removal of ballast proteins, polyphenols and polysaccharides

5. Structural analysis of polysaccharides - spectroscopic methods (vibrational spectroscopy and NMR)

6. Structural analysis of polysaccharides - separation methods (monosaccharidic composition, configuration of glycosidic bonds, molecular weight and viscosity)

7. Structural analysis of polysaccharides - thermal analysis, X-ray diffraction, microscopic methods

8. Polysaccharides as hydrocolloids - functions and properties, formation of gels and films

9. Polysaccharides as polyelectrolytes - ionization of functional groups, solubility, interaction with the oppositely charge ions (metals cations, anions of organic acids)

10. Polysaccharides as active substances in medicine - drug delivery systems, wound dressing, replacement of biological tissues

11. Polysaccharides as active substances in medicine - biologically active polysaccharides, anticoagulant and immunomodulatory properties

12. Chemical modification of polysaccharides, polysaccharide derivatives and their functions in pharmaceutical forms

13. Oligomers derived from polysaccharides, cyclodextrins, glycodendrimers - preparation and function in pharmaceutical forms

14. Environmental aspect of polysaccharides applications in pharmaceuticals

Registration requirements -
Last update: Čopíková Jana prof. Ing. CSc. (01.10.2013)

Technology of pharmacy, Biochemistry, Organic Chemistry

Teaching methods
Activity Credits Hours
Obhajoba individuálního projektu 0,5 14
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Příprava na zkoušku a její absolvování 1 28
3 / 3 84 / 84
Coursework assessment
Form Significance
Regular attendance 20
Report from individual projects 10
Examination test 50
Continuous assessment of study performance and course -credit tests 20