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Last update: Čopíková Jana prof. Ing. CSc. (15.11.2012)
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Last update: TAJ321 (18.12.2013)
Students will learn the structure, analysis, applications and benefits of polysaccharides in pharmacy. |
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Last update: TAJ321 (03.10.2013)
R: Martínková Jiřina a kol.: Farmakologie, Grada, 2007, ISBN-13: 978-80-247-1356-4 R: Lüllmann Heinz, Mohr Klaus, Wehling Martin: Farmakologie a toxikologie, Grada, 2004, ISBN 80-247-0836-1 A: Dumitriu Severien: Polysaccharides in Medicinal Applications, Marcel Dekker, INC, 1996, ISBN 0-8247-9540-7 |
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Last update: Čopíková Jana prof. Ing. CSc. (26.09.2013)
Basic Severian Dumitriu: Polysaccharides in Medicinal Applications, M. Dekker, 1996 R. H. Marchessault, François Ravenelle, Xiao Xia Zhu: Polysaccharides for drug delivery and pharmaceutical applications, American Chemical Society, 2006
Complementary Journal: Carbohydrate Polymers |
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Last update: Čopíková Jana prof. Ing. CSc. (15.11.2012)
1. Sources, function and metabolism of polysaccharides, their importance in Nature 2. Nomenclature of polysaccharides, chemical composition and major functional groups 3. Structural diversity and conformation of polysaccharides, their complexes with other molecules (proteins, polyphenols, macrocycles) 4. Procedures for isolation of polysaccharides from natural raw materials, purification and removal of ballast proteins, polyphenols and polysaccharides 5. Structural analysis of polysaccharides - spectroscopic methods (vibrational spectroscopy and NMR) 6. Structural analysis of polysaccharides - separation methods (monosaccharidic composition, configuration of glycosidic bonds, molecular weight and viscosity) 7. Structural analysis of polysaccharides - thermal analysis, X-ray diffraction, microscopic methods 8. Polysaccharides as hydrocolloids - functions and properties, formation of gels and films 9. Polysaccharides as polyelectrolytes - ionization of functional groups, solubility, interaction with the oppositely charge ions (metals cations, anions of organic acids) 10. Polysaccharides as active substances in medicine - drug delivery systems, wound dressing, replacement of biological tissues 11. Polysaccharides as active substances in medicine - biologically active polysaccharides, anticoagulant and immunomodulatory properties 12. Chemical modification of polysaccharides, polysaccharide derivatives and their functions in pharmaceutical forms 13. Oligomers derived from polysaccharides, cyclodextrins, glycodendrimers - preparation and function in pharmaceutical forms 14. Environmental aspect of polysaccharides applications in pharmaceuticals |
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Last update: Čopíková Jana prof. Ing. CSc. (01.10.2013)
Technology of pharmacy, Biochemistry, Organic Chemistry |
Teaching methods | ||||
Activity | Credits | Hours | ||
Obhajoba individuálního projektu | 0.5 | 14 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 1 | 28 | ||
3 / 3 | 84 / 84 |
Coursework assessment | |
Form | Significance |
Regular attendance | 20 |
Report from individual projects | 10 |
Examination test | 50 |
Continuous assessment of study performance and course -credit tests | 20 |