Biologically Active Natural Compounds - N342009
Title: Biologicky aktivní přírodní látky
Guaranteed by: Department of Chemistry of Natural Compounds (342)
Actual: from 2019
Semester: summer
Points: summer s.:5
E-Credits: summer s.:5
Examination process: summer s.:
Hours per week, examination: summer s.:3/0 Ex [hours/week]
Capacity: unknown / unknown (124)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Is provided by: M342001
For type:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Lapčík Oldřich prof. Dr. RNDr.
Cihlářová Petra PharmDr. Ph.D.
Interchangeability : S342009
Z//Is interchangeable with: S342009, M342001, AM342001
Examination dates   
Annotation -
Last update: TAJ342 (30.09.2013)
The course covers basic structural groups of biologically active natural compounds with its representative sources, namely in the plant kingdom. Selected pharmacologically important products of mushrooms and microorganisms are discussed. Besides pharmacological activities, discussed are also selected groups of sensorial active compounds (non-sugar artificial sweeteners, bitter compounds, olfactory active compounds). Molecular and cellular basis of activity is given for selected activities, structure-activity relationship is discussed.
Aim of the course -
Last update: TAJ342 (30.09.2013)

Students will be able to:

Give basic types and mechanisms of biological activities

Give basic structural types of primary and secondary metabolites

Give examples of important pharmacologically active compounds and its botanical sources

Determine the orientation in scientific literature in the field of phytochemistry and pharmacognosy

Literature -
Last update: TAJ342 (30.09.2013)

R: Jean Bruneton: Pharmacognosy. Lavoisier Publishing Inc., Paris, 1999, reprint 2001 (1-898298-63-7 )

A: Paul M. Dewick: Medicinal Natural Products � A Biosynthetic Approach. John Wiley & Sons Ltd., Chichester, England. 2002 (0471 49641 3)

A: Joanne Barnes, Linda A. Anderson, J. David Philipson: Herbal Medicines, Pharmaceutical Press, London, UK 2007 (978 0 85369 623 0)

Learning resources -
Last update: TAJ342 (30.09.2013)

Lecture notes

Syllabus -
Last update: TAJ342 (30.09.2013)

1. Course introduction, history, basic terms, pharmacognosy, chemosystematics

2. Principals of effects of biologically active compounds, biological activity targets at a molecular, cellular, and organ level

3. Polysaccharides: fiber, gums, slimes, pectins. Plants and microorganisms: Acacia sp., Astragalus gummifer, Ceratonia siliqua, Psilium sp., Leuconostoc sp., Gelidium sp., Glacilaria sp.

4. Specifically active proteins: enzymes, lectins, intensively sweet proteins. Plants: Carica papaya., Canavalia ensiformis, Ricinus communis, Abrus precatorius, Thaumatococcus sp., Pentadiplandra brazzeana.

5. Alkaloids. General properties, taxonomical occurrence proto alkaloids, Plants: Capsicum sp., Ephedra sp., Lophphora williamsi

6. Alkaloids affecting signal function of acetyl choline, cytostatics. Plants: Atropa belladona, Erythroxylon cocca, Nicotiana sp., Areca catechu, Conium maculatum, Papaver somniferum, Cataranthus roseus, Physostigma venenosum, Strychnos sp., Galanthus sp., Narcissus sp.

7. Ergot alkaloids, pseudoalkaloids, purine alkaloids. Plants and mushrooms: Claviceps purpurea, Aconitum sp., Veratrum sp., Coffea arabica, Camellia sinensis, Theobroma cacao, Ilex paraguayensis

8. Examples of bioactive glycosides: heart glycosides, saponins, glucosinolates, cyanogenic glycosidy. Plants: Digitalis sp., Drimia maritima, Glycyrrhiza glabra, Aesculus hippocastanum, Hedera helix, Brassica sp., Manihot esculenta.

9. Phenolic compounds I: General properties, simple phenols, phenolic acids and their esters, coumarins. Plants: Myroxylon balsamum, Rosmarinus officinalis, Salix sp., Meliotus officinalis, Heracleum sp.

10. Phenolic compounds II: Flavonoids and lignans, phytoestrogens. Plants: Silybum marianum, Fagopyrum esculentum, Glycine max., Trifolium sp., Pueraria sp., Linum usitatissimum

11. Phenolic compounds III. Tannins, chinons, orcinols and phloroglucinols. Plants: Quercus sp., Juglans regia, Lawsonia inermis, Cassia sp., Rhamnus frangula, Humulus lupulus, Cannabis sp.

12. Terpenoids I: Monoterpenes and essential oils, toxic diterpenes. Plants: Lavandula sp., Mentha sp., Thymus sp., Carum carvi, Citrus aurantium, Taxus sp., Croton sp., Daphne mezerum

13. Terpenoids II: Triterpenoids, steroids and carotenoids, vitamin A and retinoids. Plants: Betula sp., Cucurbita sp., Capsicum annuum, Crocus sp.,

14. Excursion (botanical garden)

Entry requirements - Czech
Last update: Lapčík Oldřich prof. Dr. RNDr. (19.11.2012)

Pro zahájení studia nejsou definovány žádné striktní požadavky na předchozí absolvování určitých předmětů. Při výkladu a následně i při zkoušce se ale předpokládá základní znalost organické chemie, biochemie a biologie.

Registration requirements -
Last update: TAJ342 (30.09.2013)


Biochemistry I

Organic chemistry I

Course completion requirements - Czech
Last update: Lapčík Oldřich prof. Dr. RNDr. (19.11.2012)

Předmět je zakončen zkouškou, která má písemnou a ústní část.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Práce na individuálním projektu 0,5 14
Příprava na zkoušku a její absolvování 1,5 42
Účast na seminářích 0,5 14
5 / 5 140 / 140
Coursework assessment
Form Significance
Regular attendance 20
Defense of an individual project 10
Examination test 30
Oral examination 40