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Last update: TAJ342 (30.09.2013)
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Last update: TAJ342 (30.09.2013)
Students will be able to: Design synthetic strategies for modification of polyfunctional molecules Have an overview of stereochemistry of chiral compounds |
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Last update: TAJ342 (30.09.2013)
R: Boons G.J. (red.), Carbohydrate Chemistry, Blackie 1998. R: Steglich W., et al. (red.), Natural Products, Thieme 2000.
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Last update: TAJ342 (30.09.2013)
Lecture notes |
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Last update: TAJ342 (30.09.2013)
1. Importance of saccharides in nature, building and storage saccharides, recognition at cellular level 2. Stereochemistry of saccharides, mutarotation, formulae, basics of nomenclature 3. Manipulations with polyfunctional molecule, protecting groups, deprotection 4. Preparation and importance of glycosides 5. Alkylation, acylation, oxidation, reduction, regioselectivity of reactions 6. Nucleophilic substitution, activation of hydroxy groups 7. Synthesis of derivatives (oxirans, anhydro and amino sugars, glycosyl halogenides) 8. Thio saccharides, thio glycosides, occurrence in nature, synthesis 9. Overview of important oligosaccharides, their properties and modification 10. Overview of important polysaccharides, their properties and modification 11. Biotransformations in synthesis of saccharide derivatives 12 Methods of preparation of branched saccharides 13. N- and C-glycosides 14. Practical experience with synthesis of polyfunctional compounds, rational design of compounds with potential biological activity |
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Last update: TAJ342 (30.09.2013)
Organic chemistry I |
Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.2 | 5 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 1.3 | 35 | ||
3 / 3 | 82 / 84 |
Coursework assessment | |
Form | Significance |
Regular attendance | 20 |
Oral examination | 80 |