Subjects

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Crystal engineering in pharmaceutical industry - N402069

Title:	Krystalové inženýrství pro farmaceutický průmysl
Guaranteed by:	Department of Analytical Chemistry (402)
Faculty:	Faculty of Chemical Engineering
Actual:	from 2019
Semester:	summer
Points:	summer s.:3
E-Credits:	summer s.:3
Examination process:	summer s.:
Hours per week, examination:	summer s.:2/0, Ex [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
For type:

Guarantor:	Král Vladimír prof. RNDr. DSc. Rak Jakub Ing.

Examination dates Schedule

Annotation -

Crystal engineering is a concept encompassing the design and synthesis of crystals and other supramolecular structures with desired properties. It is essential to understand and utilize intermolecular interactions, to understand how molecules aggregate in solution and how these aggregates form into crystals, what is the relationship between the structure of molecules and crystal structure, why some molecules have more than one crystal structure, why some crystalline structure contain molecules of solvent.

Last update: RAKJ (16.09.2013)

Aim of the course -

Students will understand the influence of crystal structure on the physical properties of materials, design and preparation of crystals of the desired properties.

Last update: RAKJ (16.09.2013)

Literature -

R: Scheel H.J., Fukuda T., Crystal Growth Technology, Wiley, 2004, ISBN: 978-0-471-49524-6.

A: Tilley, R.J.D., Crystals and Crystal Structures, Wiley, 2006, ISBN: 978-0-470-01820-0.

A: Tieking E.R.T., Vittal J. - (Editors), Frontiers in Crystal Engineering, Wiley, 2005, ISBN: 978-0-470-02258-0.

Last update: VED402 (01.10.2013)

Learning resources -

Tilley, R.J.D., Crystals and Crystal Structures, Wiley, 2006, ISBN: 978-0-470-01820-0

Last update: RAKJ (16.09.2013)

Syllabus -

1. Historical Introduction.

2. Crystals and crystal structure.

3. Description of the crystal structure.

4. Analysis of the crystal structure.

5. Thermodynamic fundamentals of phase transitions and their applications in crystal growth.

6. Influence the crystal structure at the molecular structure.

7. Crystal engineering of pharmaceutical polymorphs, salts and co-crystals.

8. Computer simulations of crystals.

9. Defects modulated structure and quasi-crystals.

10. 3D symmetry.

11. Molecular aspects polymorphous crystallization.

12. Supramolecular interactions and control of molecular architecture.

13. Steric control of the supramolecular aggregation.

14. examination test

Last update: RAKJ (17.09.2013)

Registration requirements -

none

Last update: RAKJ (16.09.2013)

Teaching methods
	Activity	Credits	Hours
	Účast na přednáškách	1	28
	Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi	1	28
	Příprava na zkoušku a její absolvování	1	28
		3 / 3	84 / 84

Coursework assessment
Form	Significance
Examination test	50
Oral examination	50