SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Biological Process Engineering - N409012
Title: Inženýrství biologických procesů
Guaranteed by: Department of Chemical Engineering (409)
Faculty: Faculty of Chemical Engineering
Actual: from 2021
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1, C+Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: cancelled
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Guarantor: Schreiber Igor prof. Ing. CSc.
Přibyl Michal prof. Ing. Ph.D.
Hasal Pavel prof. Ing. CSc.
Is interchangeable with: B409009, AB409009
Examination dates   Schedule   
Annotation -
The course provides basic overview of quantitative description of processes taking place in enzyme catalysis and in bioreactors. It builds on the principles of chemical engineering, notably on mass and energy balances with the use of kinetic relations for mass transfer and for the biochemical conversion. Student will learn about enzyme processes and bioprocesses but also about unit operations preceding or following the bioreaction.
Last update: SEK409 (17.12.2013)
Aim of the course -

Students will be able to:

apply chemical engineering methods to biological processes

describe kinetics of biomass and product formation

describe quantitatively and design a simple bioreactor - chemostat

Last update: Schreiber Igor (27.09.2013)
Literature -

R: Shuler M. L., Kargi F., Bioprocess Engineering. Basic Concepts, Prentice Hall, Upper Saddle River, 2002, 0-13-081908-5

A: Doran P., Bioprocess Engineering Principles, Academic Press, 1995, New York, 9780122208553

Last update: SEK409 (08.10.2013)
Learning resources -

lecture notes available at

Last update: Schreiber Igor (27.09.2013)
Syllabus -

1. Introduction to the studies. Engineering and biological access to problem solving (production penicillin).

2. Basic piece of knowledge from cellulate biology.

3. Enzymes: classification, molecular structure, common characteristics and characteristics of enzymes.

4. Enzyme system kinetics, kinetic models, determination of kinetic parameters.

5. Immobilization of enzymes and microbial cells, used techniques and methods.

6. Transport processes in systems with immobilize enzymes. Manufacturing of enzymes, application of enzymes.

7. Simulation of kinetics microbial growth and performance metabolites, stoichiometry.

8. Influence of cultural conditions on kinetics of growth microbial cells.

9. Cellular growth and performance metabolites in batch cultures.

10. Cellular growth and performance metabolites in continuous cultures.

11. Fermenters, selection cultural method, bath and continuous bioreactors.

12. Simulation of fermenters, immobilize microbial cell, fermentation solid - state. Transmission masses.

13. Scale-up criteria, running and drive bioreactors. Simulation of bioreactors.

14. Aeration, sterilization.

Last update: Schreiber Igor (11.09.2013)
Registration requirements -

Unit operations of Chemical Engineering I

Last update: Schreiber Igor (01.10.2013)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 0.5 14
4 / 4 112 / 112
Coursework assessment
Form Significance
Regular attendance 30
Continuous assessment of study performance and course -credit tests 35
Oral examination 35