SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Organic Synthesis - P110003
Title: Organická syntéza
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Cibulka Radek prof. Ing. Ph.D.
Kundrát Ondřej Ing. Ph.D.
Jurok Radek Ing. Ph.D.
Interchangeability : D110003
Is interchangeable with: AP110003
Annotation -
Last update: Cibulka Radek prof. Ing. Ph.D. (04.07.2018)
The subject is focused on exercising transformations in organic synthesis which is followed by introduction of novel approaches used for selective introduction and transformation of functional groups including application of protecting groups.
Aim of the course -
Last update: Cibulka Radek prof. Ing. Ph.D. (04.07.2018)

Students will be able to:

apply methods for introduction of organic functional groups

transform and remove various functionalities in organic molecules

construct various carbon chains of complex organic molecules

selectively protect functional groups in multi-functional compounds

design syntheses of organic compounds on intermediate level

Literature -
Last update: Kundrát Ondřej Ing. Ph.D. (10.07.2018)

R: Carey, Sundberg: Advanced Organic Chemistry, 5th Ed., Part B. Springer, New York 2007, 978-0387683461.

A: Smith, M.: Organic Synthesis, 4th Ed. Academic Press, 2016, 978-0128007204.

A: Smith, M.: March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th Ed. Wiley, 2013, 978-0470462591.

Learning resources -
Last update: Pátková Vlasta (18.04.2018)

Teaching support to lectures at the lecturer

Syllabus -
Last update: Cibulka Radek prof. Ing. Ph.D. (04.07.2018)

1. Redox reactions in organic chemistry - introduction.

2. Reduction methods in organic chemistry. Selectivity.

3. Oxidation - tool to increase oxidation state of the molecule. Modern stoichiometric and catalytic oxidation method.

4. Halogenation. Chemoselectivity and regioselectivity.

5. Alkylation a acylation reactions - introduction. Alkylations and acylation in aromatic compounds, selectivity.

6. Selective alkylation - tool for synthesis of amines, ethers and thioethers.

7. C-alkylation: important tool for carbon chain construction.

8. Selective introduction of nitrogen-containing functional groups.

9. Transformation of nitrogen-containing derivatives.

10. Formation of organometallic compounds.

11. Aplication of organometallic compounds.

12. Elimination reactions in organic synthesis. Chemoselectivity and regioselectivity.

13. Modern methods for preparation and synthesis of carbonyl compounds and carboxylic acids.

14. Principle of protection in organic synthesis. Selectivity of protection and deprotection.

Course completion requirements -
Last update: Cibulka Radek prof. Ing. Ph.D. (04.07.2018)

It is compulsory to pass two seminar tests with the average result at least 50%,written examination test with the result at least 50%, and finally to pass successfuly the oral examination.

 
VŠCHT Praha