SubjectsSubjects(version: 955)
Course, academic year 2019/2020
Organic Synthesis - P110003
Title: Organická syntéza
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2019 to 2021
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:3/0, other [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Cibulka Radek prof. Ing. Ph.D.
Kundrát Ondřej Ing. Ph.D.
Jurok Radek Ing. Ph.D.
Is interchangeable with: AP110003
Examination dates   Schedule   
Annotation -
The subject is focused on exercising transformations in organic synthesis which is followed by introduction of novel approaches used for selective introduction and transformation of functional groups including application of protecting groups.
Last update: Cibulka Radek (04.07.2018)
Aim of the course -

Students will be able to:

apply methods for introduction of organic functional groups

transform and remove various functionalities in organic molecules

construct various carbon chains of complex organic molecules

selectively protect functional groups in multi-functional compounds

design syntheses of organic compounds on intermediate level

Last update: Cibulka Radek (04.07.2018)
Literature -

R: Carey, Sundberg: Advanced Organic Chemistry, 5th Ed., Part B. Springer, New York 2007, 978-0387683461.

A: Smith, M.: Organic Synthesis, 4th Ed. Academic Press, 2016, 978-0128007204.

A: Smith, M.: March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th Ed. Wiley, 2013, 978-0470462591.

Last update: Kundrát Ondřej (18.06.2024)
Learning resources -

Teaching support to lectures at the lecturer

Last update: Pátková Vlasta (18.04.2018)
Syllabus -

1. Redox reactions in organic chemistry - introduction.

2. Reduction methods in organic chemistry. Selectivity.

3. Oxidation - tool to increase oxidation state of the molecule. Modern stoichiometric and catalytic oxidation method.

4. Halogenation. Chemoselectivity and regioselectivity.

5. Alkylation a acylation reactions - introduction. Alkylations and acylation in aromatic compounds, selectivity.

6. Selective alkylation - tool for synthesis of amines, ethers and thioethers.

7. C-alkylation: important tool for carbon chain construction.

8. Selective introduction of nitrogen-containing functional groups.

9. Transformation of nitrogen-containing derivatives.

10. Formation of organometallic compounds.

11. Aplication of organometallic compounds.

12. Elimination reactions in organic synthesis. Chemoselectivity and regioselectivity.

13. Modern methods for preparation and synthesis of carbonyl compounds and carboxylic acids.

14. Principle of protection in organic synthesis. Selectivity of protection and deprotection.

Last update: Cibulka Radek (04.07.2018)
Course completion requirements -

It is compulsory to pass two seminar tests with the average result at least 50%,written examination test with the result at least 50%, and finally to pass successfuly the oral examination.

Last update: Cibulka Radek (04.07.2018)