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Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
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Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
Students will be able to: Use nomenclature of retrosynthetic analysis Apply retrosynthetic analysis to design synthesis of polyfunctional organic compounds Recognize suitable structural elements suitable for disconnection of complex molecules Understand logic of total synthesis of natural compounds |
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Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
R: Warren S., Wyatt P.: Organic synthesis - The disconnection approach, 2nd Edition, John Wiley, 2008, 9780470712368 R: Wyatt P., Warren S.: Organic Synthesis - Strategy and Control, John Wiley, 2007, 9780470489405 A: Carruthers W., Coldham I.: Modern methods in organic synthesis, Publisher: Cambridge University Press, 2004, 9780521778305 A: Warren S., Wyatt P.: Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition, John Wiley, 2009, 9780470712276
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Last update: Pátková Vlasta (18.04.2018)
http://uoch.vscht.cz/cz/download/synton.pdf |
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Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
1. The disconnection approach. Synthons and their preparation. 2. One and two group C-X disconnections. 3. One group C-C disconnections 4. Alkene and alkyne synthesis. Synthesis of biaryls. 5. Synthesis of 1,3- and 1,5-difunctionalised compounds. 6. Synthesis of 1,2-, 1,4- and 1,6-difunctionalised compounds. 7. Strategy of ring synthesis. 8. Synthesis of heterocyclic and heteroaromatic compounds. 9. Chemoselectivity, regioselectivity and stereoselectivity in organic synthesis. 10. Retron, key structural element for complex compound disconnection. 11. Modern methods for transformations of functional groups. 12. Linear and convergent synthesis. 13. Modern approach to total synthesis of natural compounds - recent examples (workshop). 14. Modern approach to total synthesis of natural compounds - recent examples (workshop). |
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Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
It is compulsory to prepare project on the synthesis of natural compound, to pass written examination test with the result at least 60%, and finally to pass successfuly the oral examination. |