SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Supramolecular Chemistry - P110011
Title: Supramolekulární chemie
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Lhoták Pavel prof. Ing. CSc.
Interchangeability : D110020
Is interchangeable with: AP110011
Annotation -
Last update: Lhoták Pavel prof. Ing. CSc. (03.07.2018)
Supramolecular chemistry is a multidisciplinary discipline dealing with the study of noncovalent interactions and their application in the design and synthesis of molecular systems possessing defined properties and functions (nanomachinery). It combines the knowledge of organic chemistry and biochemistry with other chemical branches, such as inorganic, physical, analytical and theoretical chemistry. The significance of supramolecular chemistry was currently underlined by the second Nobel Prize (2016) awarded for the development of this field. The domain of supramolecular chemistry is the design of novel receptors for selective complexation of selected ions and/or neutral molecules (host-guest chemistry), spontaneous formation of well-defined aggregates (self-assembly), molecular recognition, the synthesis and application of topological isomers (catenanes, rotaxanes, knotanes). The basic concepts of supramolecular chemistry together with the most frequently used families of highly preorganised compounds (crownethers, calixarenes, cyclodextrins, cryptophanes, porphyrins, resorcarenes, cucurbiturils, fullerenes, dendrimers etc.) are discussed as well.
Aim of the course -
Last update: Lhoták Pavel prof. Ing. CSc. (02.07.2018)

Students will be able to:

• recognise the noncovalent interactions acting in a specific system

• use the knowledge of noncovalent interactions for design of receptor suitable for the complexation of cations and/or anions)

• design the 3D structure/shape of receptor for the complexation of neutral molecule

• choose analytical methods suitable for the study of a given complex

• suggest methods for the evaluation of the stability constants and thermodynamic parameters of the host-guest interaction

• apply the principals of "self-assembly" for the synthesis of topological isomers

• use the concepts of supramolecular chemistry in the advanced organic synthesis

Literature -
Last update: Lhoták Pavel prof. Ing. CSc. (16.09.2018)

(R) J. W. Steed, J. L. Atwood: Supramolecular Chemistry, 2nd Edition, Wiley 2009. ISBN 9780470512340

(A) J. W. Steed, J. L. Atwood (Eds.): Encyclopedia of Supramolecular Chemistry, 2004, CRC Press, ISBN 9780824750565

(A) Beer P. D., Gale P. A., Smith D. K.: Supramolecular Chemistry, Oxford Chemistry Primers, Oxford University Press 1999. 0198504470

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https://onlinelibrary.wiley.com/results/global-subject-codes/ch85?target=topic-title-results

(Wiley Online Library available from VSCHT (UCT) intranet, more than 50 books focused on supramolecular chemistry)

Learning resources -
Last update: Lhoták Pavel prof. Ing. CSc. (02.07.2018)

http://intranet.vscht.cz/suprachemie

(available at VSCHT (UCT) intranet, definition of basic terms, lectures in pdf format)

https://onlinelibrary.wiley.com/results/global-subject-codes/ch85?target=topic-title-results

(Wiley Online Library available at VSCHT (UCT) intranet, more than 50 books focused on supramolecular chemistry)

Syllabus -
Last update: Lhoták Pavel prof. Ing. CSc. (02.07.2018)

• What is supramolecular chemistry? Basic definitions and concepts.

• Complexation of cations, anions and neutral compounds, chiral recognition.

• Noncovalent interactions and their applications.

• Structure determination, stability constant assignment and the evaluation of thermodynamic parameters of the corresponding supramolecular phenomenon (host-guest chemistry).

• Overview of the most frequently used families of macrocyclic compounds.

• Modular approach - the coordination chemistry of pyridines and bipyridines.

• Biochemical applications of supramolecular chemistry

• Pricipals of self-assembly and their applications.

• Topological isomers (rotaxanes, catenanes, knotanes), nanomachines.

• Liquid crystals.

• Interfacial phenomena (micelles, Langmuir-Blodget, SAM)

• Carbon allotropes (fullerenes, nanotubes, graphene).

• Dendrimers and supramolecular chemistry of polymers.

Course completion requirements -
Last update: Lhoták Pavel prof. Ing. CSc. (02.07.2018)

PowerPoint presentation on selected topic (20%)

Final test (40%)

Oral examination (40%)

 
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