SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Transition Metals in Organic Synthesis - P110013
Title: Přechodné kovy v organické syntéze
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Tobrman Tomáš doc. Ing. Ph.D.
Interchangeability : D110026
Is interchangeable with: AP110013
Annotation -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)
The course describes basic principles of organometallic chemistry including practical applications in the chemical industry and in the organic synthesis.
Aim of the course -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

Students will be able to:

distinguish an influence of reaction conditions on the reaction outcome

understand the mechanisms of transition metal-catalyzed reactions

propose synthesis of organic compounds using chemistry of transition metals

Literature -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (20.08.2018)

R: Robert H. Crabtree: The Organometallic Chemistry of the Transition Metals, 2014, John Wiley & Sons, Inc., DOI:10.1002/9781118788301

A: Christoph Elschenbroich: Organometallics, 2016, John Wiley & Sons, Inc., ISBN: 978-3-527-80516-7

Learning resources -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

none

Teaching methods -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

lectures with examples

Requirements to the exam -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

none

Syllabus -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

The subject covers following topics:

  • General terms: formal oxidation state, 18-electron rule, bonding in organometallic compounds

  • Classification and properties of ligands: halides, oxygen and nitrogen ligands, phosphines, hydrides, alkyls, alkenyls, s-aryls, acyl and NHC ligands.

  • Reactions of coordinated alkenes, arenes and polyenes with nucleophiles.

  • Alkenes and alkynes in transition metal catalyzed reactions: hydrogenation, hydrosylilation, hydroboration, hydrometallation, hydrocarbonylation, transition metal-catalyzed polymerization.

  • Cross-coupling reactions: general terms and introduction, an application of activated C-O, C-N in cross-coupling reactions, an influence of additives on reaction outcomes, Buchwald-Hartwig reaction.

  • Activation of C-H and C-C bond: the mechanisms and practical applications.

  • Transition metal-catalyzed multicomponent reactions: general terms, examples of multicomponent reactions.

  • Fischer and Schrock carbene complexes: properties and applications in organic synthesis (metathesis reactions)

  • Transition metal-catalyzed substitution of allylic substrates, the mechanisms and practical applications, asymetric allylic substitution.

Registration requirements -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (25.06.2018)

none

Course completion requirements -
Last update: Pátková Vlasta (18.04.2018)

Student has to gain at least 70% from two written tests during the semester and to pass the oral exam.

 
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