SubjectsSubjects(version: 894)
Course, academic year 2021/2022
  
Chemistry of Pharmaceuticals - P110018
Title: Farmakochemie
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2021
Semester: summer
Points: summer s.:0
E-Credits: summer s.:0
Examination process: summer s.:
Hours per week, examination: summer s.:0/0 other [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Rádl Stanislav doc. Ing. CSc.
Zezula Josef Ing. Ph.D.
Annotation -
Last update: Fialová Jana (24.04.2020)
The subject gives an overview throughout principal therapeutic groups. The given examples of drugs are described in the following scheme: discovery, development and the life cycle. The selected drugs from each therapeutic group are typical illustrative examples and they are presented as case studies. The emphasis is on logical connection of the knowledge of organic chemistry, medicinal chemistry, and pharmacology.
Aim of the course -
Last update: Fialová Jana (24.04.2020)

Students will be able to:

be informed on therapeutic groups,

identify pharmacophores in these groups and know principles of their phyrmacodynamics,

know chemical and pharmaceutical databases and do search in these databases focused on chemical and pharmacological data and on syntheses of drugs (both generic and the new ones being in phase III of clinical testing),

design an optimal synthetic approach to a generic substance on the basis of critical evaluation of pieces of information found in chemical and pharmaceutical literature.

Literature -
Last update: Fialová Jana (24.04.2020)

R: Vardanyan R., Hruby V. : Syntheses of Essential Drugs. Elsevier, 2006.

A: Patrick G. L. : An Introduction to Medicinal Chemistry. 3rd ed. Oxford University Press, Oxford 2005.

A: Kleemann A.; Engel J.; Kutscher B.; Reichert D.: Pharmaceutical Substances, Syntheses, Patents, Applications. 5th ed. Stuttgart : Thieme, 2009. 9783135584058

Syllabus -
Last update: Fialová Jana (24.04.2020)

1. Introduction, general principles, fundametals of pharmacology.

2. History of the drug discovery. Case studies of drugs from natural patterns and drugs resulting form selective optimization of the side activities of drugs.

3. Painkillers. Case study: modern antimigrain drugs.

4. Central nervous system drugs. Case study: oxetines as antidepressants.

5. Central nervous system drugs. Case study: benzodiazepines.

6. Central nervous system drugs. Case study: modern hypnotics.

7. Autonomic nervous system drugs. Case study: sympatholytics and their applicatiuon in therapy.

8. Antihistamines and antiallergics. Case study: H1 antihistamines.

9. Cardiovascular drugs. Case study: statins as antihyperlipidemics.

10. Cardiovascular drugs. Case study: antihypertensives affecting renin-angiotensin system; ACE inhibitors, angiotensin II antagonists.

11. Drugs used in the treatment of gastrointestinal tract. Case study: laxatives and antidiarrheal agents.

12. Drugs used in the treatment of gastrointestinal tract. Case study: prazoles as antiulcer drugs.

13. Chemotherapeutic drugs. Case study: quinolones.

14. Cancer chemotherapy. Case study: targeted drug delivery.

Course completion requirements -
Last update: Fialová Jana (24.04.2020)
  • preparation and defence of a literature search (significance 20 %)
  • written exam (significance 30 %)
  • oral exam (significance 50 %)
 
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