SubjectsSubjects(version: 908)
Course, academic year 2021/2022
Industrial synthesis of fine chemicals - P110023
Title: Průmyslová syntéza speciálních chemikálií
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2021 to 2021
Semester: summer
Points: summer s.:0
E-Credits: summer s.:0
Examination process: summer s.:
Hours per week, examination: summer s.:2/0, other [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Vyskočilová Eliška doc. Ing. Ph.D.
Annotation -
Last update: Fialová Jana (05.05.2022)
Synthetic strategies based on organocatalyzed processes, such as stereoselective aldol and Mannich reaction, Michael and Diels-Alder addition, Friedel-Crafts-like functionalization, allylation, transfer hydrogenation, and hydrosilylation, etc.
Aim of the course -
Last update: Fialová Jana (05.05.2022)

Students will be able to:

perceive organocatalytic reactions in terms known to you from the previous courses on organic chemistry and biochemistry

recognise and understand the basic organocatalytic reactions

understand the mechanisms of organocatalyzed reactions and to broaden the mechanistic understanding in general organic chemistry.

identify conditions required for catalytic cycles to be efficient.

use organocatalysis for designing key steps in the synthesis of organic molecules.

Literature -
Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)

R: Wiley-VCH, Ullmann's Fine Chemicals, Wiley-VCH; 1st edition (January 7, 2014), ISBN 978-3527334773

A: Stephen O. Duke, Per Kudsk, Keith Solomon, Pesticide Dose: Effects on the Environment and Target and Non-Target Organisms, ACS Symposium series, 2017, ISBN13: 9780841232112, DOI: 10.1021/bk-2017-1249

A: F. Muller, Agrochemicals: Composition, Production, Toxicology, Applications, Wiley-VCH 2000 ISBN-13 ‏ : ‎ 978-3527298525

A: D. Cairns, Essentials of Pharmaceutical Chemistry 4th Edition, Pharmaceutical Press; 4th edition (January 1, 2012), ISBN 978-0853699798

A: D. Myers, Surfactant Science and Technology, Wiley; 4th edition (June 23, 2020). ISBN 978-1119465850

A: Hans Zweifel, Plastics Additives Handbook, Hanser Publications; 6th edition (June 4, 2009), ISBN 978-1569904305

Learning resources -
Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)

Syllabus -
Last update: Fialová Jana (05.05.2022)

1. Introduction.

2. Catalysis via Enamines; Aldol reactions, Mannich reactions,α-Heteroatom Functionalization, Michael Additions.

3. Catalysis via Iminium Ions; Cycloadditions, Michael additions, Epoxidations.

4. Brønsted Acids as Catalysts; Michael addition, Hydrocyanation, Mannich reaction, Aza-Henry reaction, Aza-Friedel-Crafts reaction, Pictet-Spengler Reaction, Transfer Hydrogenation, Morita-Baylis-Hillman Reaction, Diels-Alder Reaction.

5. Lewis Bases as Catalysts; Allylation of Aldehydes, Aldol-Type Reactions, Hydrocyanation, Hydrosilylation, Reduction of Imines, Reduction of Ketones.

6. Epoxidation.

Course completion requirements -
Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)

Activity on the lectures and sucesfully passed oral exam.