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Last update: Fialová Jana (05.05.2022)
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Last update: Fialová Jana (05.05.2022)
Students will be able to: perceive organocatalytic reactions in terms known to you from the previous courses on organic chemistry and biochemistry recognise and understand the basic organocatalytic reactions understand the mechanisms of organocatalyzed reactions and to broaden the mechanistic understanding in general organic chemistry. identify conditions required for catalytic cycles to be efficient. use organocatalysis for designing key steps in the synthesis of organic molecules.
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Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)
R: Wiley-VCH, Ullmann's Fine Chemicals, Wiley-VCH; 1st edition (January 7, 2014), ISBN 978-3527334773
A: Stephen O. Duke, Per Kudsk, Keith Solomon, Pesticide Dose: Effects on the Environment and Target and Non-Target Organisms, ACS Symposium series, 2017, ISBN13: 9780841232112, DOI: 10.1021/bk-2017-1249 A: F. Muller, Agrochemicals: Composition, Production, Toxicology, Applications, Wiley-VCH 2000 ISBN-13 : 978-3527298525 A: D. Cairns, Essentials of Pharmaceutical Chemistry 4th Edition, Pharmaceutical Press; 4th edition (January 1, 2012), ISBN 978-0853699798 A: D. Myers, Surfactant Science and Technology, Wiley; 4th edition (June 23, 2020). ISBN 978-1119465850 A: Hans Zweifel, Plastics Additives Handbook, Hanser Publications; 6th edition (June 4, 2009), ISBN 978-1569904305 |
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Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)
https://en.wikipedia.org/wiki/Fine_chemical |
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Last update: Fialová Jana (05.05.2022)
1. Introduction. 2. Catalysis via Enamines; Aldol reactions, Mannich reactions,α-Heteroatom Functionalization, Michael Additions. 3. Catalysis via Iminium Ions; Cycloadditions, Michael additions, Epoxidations. 4. Brønsted Acids as Catalysts; Michael addition, Hydrocyanation, Mannich reaction, Aza-Henry reaction, Aza-Friedel-Crafts reaction, Pictet-Spengler Reaction, Transfer Hydrogenation, Morita-Baylis-Hillman Reaction, Diels-Alder Reaction. 5. Lewis Bases as Catalysts; Allylation of Aldehydes, Aldol-Type Reactions, Hydrocyanation, Hydrosilylation, Reduction of Imines, Reduction of Ketones. 6. Epoxidation.
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Last update: Vyskočilová Eliška doc. Ing. Ph.D. (09.05.2022)
Activity on the lectures and sucesfully passed oral exam. |