SubjectsSubjects(version: 949)
Course, academic year 2023/2024
Drug design and discovery - P110025
Title: Návrh a vývoj léčiv
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2022
Semester: summer
Points: summer s.:0
E-Credits: summer s.:0
Examination process: summer s.:
Hours per week, examination: summer s.:2/0, other [HT]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Teaching methods: full-time
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Brancale Andrea prof. Ph.D.
Annotation -
Last update: Cibulka Radek prof. Ing. Ph.D. (06.07.2022)
The course will cover the main aspects of Drug Design and Discovery, with a more particular emphasis on the medicinal chemistry methods and techniques used in this field. Some of the biological aspects, essential to the overall understanding of the topic, will also be covered.
Aim of the course -
Last update: Cibulka Radek prof. Ing. Ph.D. (06.07.2022)

Students will be able to:

understand approaches to suggest suitable target

understand principles of basic computational approaches for drug design

understand approaches to develop leading structure

know modern approaches for drug discovery.

Literature -
Last update: Cibulka Radek prof. Ing. Ph.D. (06.07.2022)

R:K. Stromgaard, P. Krogsgaard-Larsen, U. Madsen (Eds.): Textbook of Drug Design and Discovery, CRC Press, 5th Edition 2016; ISBN 9781032339948

R:R. B. Silverman, M. W. Holladay: The Organic Chemistry of Drug Design and Drug Action, Academic Press 2014; ISBN 978-0-12-382030-3

A: C. Rostron: Drug Design and Development, Oxford 2020; ISBN: 9780198749318

Learning resources -
Last update: Fialová Jana (05.05.2022)

Syllabus -
Last update: Cibulka Radek prof. Ing. Ph.D. (06.07.2022)

1. The Drug Design and Discovery process

2. Selecting the right target

3. How drugs work

4. Computer-aided drug design I: Structure-Based Drug Design

5. Computer-aided drug design I: Ligand-Based Drug Design

6. Natural compounds in Drug Discovery

7. Fragment-Based Drug Design

8. Hit discovery and lead optimisation I: Structure-Activity Relationships

9. Hit discovery and lead optimisation II: Hit-to-Lead

10. Hit discovery and lead optimisation III: Lead Optimisation

11. Prodrugs

12. Recent advances in Drug Design and Medicinal Chemistry

13. Drugs and their therapeutic landscape

14. Decision making in Drug Discovery

Course completion requirements -
Last update: Fialová Jana (05.05.2022)

It is compulsory to pass written examination test.