SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Pharmaceutical Dosage Forms - P111007
Title: Lékové formy
Guaranteed by: Department of Organic Technology (111)
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0 other [hours/week]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Zbytovská Jarmila doc.Mgr. Dr.rer.nat.
Interchangeability : D111024
Is interchangeable with: AP111007
Annotation -
Last update: Pátková Vlasta (30.05.2018)
The subject is focused on technologies of drug formulation. Particular drug forms are shown from two different points of views: the physical-chemical on one hand and the organism - drug form interaction on the other hand. Among others the issues concerning selection of appropriate excipients, drug formulation, quality and stability of dosage forms are discussed. Biopharmaceutical and pharmacokinetic aspects are presented as well.
Aim of the course -
Last update: Pátková Vlasta (30.05.2018)

Students will be able to:

  • apply physical-chemical backgrounds in drug formulation
  • evaluate the pros and cons of the particular dosage forms in concrete cases, including manufacturing
  • understand issues of selection of appropriate excipients; know their classification and utilization
  • independently solve model case studies on drug formulation and stability
Literature -
Last update: Pátková Vlasta (30.05.2018)

(R) European and Czech Pharmacopeia

(R) Komárek P., Rabišková M.: Technologie léků. Galén 2006. ISBN 80-7262-423-7.

(A) Aulton M.: Pharmaceutics: The Science of Dosage Form Design. Churchill Livingstone 2002. ISBN 0443055173.

(A) Voigt R., Fahr A.: Pharmazeutische Technologie. Deutscher Apotheker Verlag, 2010. ISBN 9783769250039.

(A) Bauer K.: Lehrbuch der Pharmazeutischen Technologie. Wissenschaftliche Verlagsgesellschaft Stuttgart, 2006. ISBN 9783804722224.

(A) Mäder K., Weidenauer U.: Innovative Arzneiformen. Wissenschaftliche Verlagsgesellschaft Stuttgart, 2009. ISBN 978-3-8047-2455-6.

(A) Leuenberger H.: Martin Physikalische Pharmazie. Wissenschaftliche Verlagsgesellschaft, 2002. ISBN 978-3-8047-1722-0.

(A) Allen L V., Popovich N.G., Ansel H.C.: Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, Ninth Ed., 2011. Walters Kluwer, Lippincott Williams & Wilkins, ISBN 978-7817-7934-0.

Journals:

(A) Advanced Drug Delivery Reviews

(A) Pharmaceutical Research

(A) International Journal of Pharmaceutics

(A) European Journal of Pharmaceutics and Biopharmaceutics

+ further texts according to particular issues

Teaching methods -
Last update: Zbytovská Jarmila doc.Mgr. Dr.rer.nat. (23.10.2018)

lectures, individual project preparation

Syllabus -
Last update: Pátková Vlasta (30.05.2018)

1. General definitions, classification of drug forms, pharmacopoeia and other standards.

2. Physically-chemical backgrounds of drug formulation.

3. Preformulation of drugs.

4. Biopharmaceutics.

5. Pharmaceutical excipients.

6. Oral administration: fluid (solutions, suspensions emulsions) and solid (powders, granules, capsules, tablets) dosage forms.

7. Parenteral administration: injections, infusions, implants and others.

8. Topical administration: into the respiratory tract; ocular and auricular dosage forms; rectal, uretral and vaginal dosage forms; dermal and transdermal fluid preparations: fluid (solutions, suspensions emulsions), semisolid (oinments, creams, gels, pastes) and solid (suppositories).

9. Modern dosage forms (with modified drug liberation; with drug targeting).

10. Pharmaceutical packaging.

11. Stability of pharmaceutical preparations.

Course completion requirements -
Last update: Zbytovská Jarmila doc.Mgr. Dr.rer.nat. (23.10.2018)

Project presentation and final exam.

Coursework assessment
Form Significance
Defense of an individual project 40
Oral examination 60

 
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