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Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
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Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
Students obtain: • theoretical basics of chiroptical spectroscopy • knowledge of instrumentation of the variants of chiroptical methods • knowledge of the measurement methodology • application of chiroptical method in conformational analysis of small molecules and biomolecules • application of chiroptical spectroscopies in biologically important interactions and chiral supramolecular systems • participation in the demo measurements of electronic and vibrational dichroic spectra |
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Last update: Setnička Vladimír prof. Ing. Ph.D. (12.10.2018)
R: Urbanová M., Maloň P. Circular Dichroism Spectroscopy v Analytical Methods in Supramolecular Chemistry (Schalley C. A., Ed.), Wiley VCH: Weinheim, Germany, Second, Completely Revised and Enlarged Edition, 2012, str. 337-369.ISBN: 978-3-527-32982-3. http://onlinelibrary.wiley.com/book/10.1002/9783527610273
A: Setnička V., Urbanová M. Spektroskopie cirkulárního dichroismu v Moderní přístupy k farmaceutické analýze (Dohnal J., Jampílek J., Král V., Řezáčová A., Eds.), Farmaceutická fakulta Veterinární a farmaceutické univerzity Brno: Brno, 2010, kapitola 4.6. |
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Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
Analýza chirálních sloučenin (Tesařová E., Ed.), Pražské analytické centrum inovací: Praha, 2007, ISBN: 978-80-86238-23-4 |
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Last update: Urbanová Marie prof. RNDr. CSc. (03.09.2018)
lectures participation in the laboratory demonstration of measurement, practicals |
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Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
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Last update: Setnička Vladimír prof. Ing. Ph.D. (16.09.2018)
1. Molecular chirality, polarization of radiation utilized in chiroptical methods 2. Theoretical basics of chiroptical methods, observable quantities (circular dichroism, ellipticity, optical rotatory dispersion, dissymmetry factor) 3. Interaction of circularly polarized radiation with matter, rotational strength of transition, relation between observables and structure of chiral molecules 4. Methodology of circular dichroism measurements, photoelastic modulator and dedicated devices 5. Electronic circular dichroism, instrumentation, how to obtain reliable spectra 6. Vibrational circular dichroism, its particularity, instrumentation, how to obtain reliable spectra and structural data 7. Variants of chiroptical methods 1: optical rotation and optical rotatory dispersion, fluorescence detected circular dichroism and their instrumentation 8. Variants of chiroptical methods 2: varianty chiroptických metod 2: circularly polarized luminescence, magnetic optical activity and their instrumentation 9. Raman optical activity and its instrumentation 10. Processing chiroptical data, ab initio calculations of chiroptical properties 11. Application of circular dichroism generally and in conformational study of biomolecules 12. Application of circular dichroism in study of biologically important interactions and of chiral supramolecular systems 13. Demo experiments in vibrational circular dichroism laboratory 14. Demo experiments in electronic circular dichroism laboratory |
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Last update: Urbanová Marie prof. RNDr. CSc. (01.09.2018)
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Last update: Urbanová Marie prof. RNDr. CSc. (03.09.2018)
written examination test participation in the laboratory demonstration of measurement |