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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
Students will know:
basic pharmacological terms
methods of drug development and phases of drug testing
main therapeutic groups of drugs
pharmacophores of the most frequently used drugs and the principles of their modes of action
syntheses of the most frequently used drugs |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
R: Vardanyan R., Hruby V. : Syntheses of Essential Drugs. Elsevier, 2006. 9780444521668 R: Patrick G. L.: An Introduction to Medicinal Chemistry. 6th ed. Oxford University Press, Oxford 2017. 9780198749691 R: Kleemann A.; Engel J.; Kutscher B.; Reichert D.: Pharmaceutical Substances, Syntheses, Patents, Applications. 5th ed. Stuttgart : Thieme, 2009. 9783135584058 All books are available at UCT Prague in the Central Library. |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
EXAMINATION
Before the oral examination, a written examination test is taken which has two parts, the overall time limit (parts A+B) is 100 minutes.
Part A: basic organic chemistry related to the API chemistry) and basid knowledge of Pharmacology (50 marks);
Part B: advanced organic chemistry focusing on API syntheses and on medicinal chemistry (50 marks);
The oral part of the examination only takes place if the student obtained at least 35 marks in the part A and at least 50 marks in total in the parts A and B of the written examination. If the student fails the examination, he/she is entitled to repeat it up to twice (i.e. each student is entitled one regular examination and two resits). |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
1. Introduction. Basic terms and definitions 2. Introduction to pharmacology: pharmacokinetics and pharmacodynamics 3. Drug design and development; drug registration 4. Analgesics-antipyretics, non-steroidal anti-inflammatory agents 5. Opioid analgesics 6. Central nervous system drugs: anaesthetics, sedatives, hypnotics 7. Central nervous system drugs: psychiatric drugs 8. Autonomous nervous system drugs: sympathomimetics and sympatholytics 9. Autonomous nervous system drugs: parasympathomimetics and parasympatholytics 10. Local anaesthetics and myorelaxants 11. Antihistamines and antiallergics; treatment of cough 12. Cardiovascular system drugs 13. Digestive tract therapeutic agents 14. Antiseptics and antiinfective agents |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
Fundamentals of Organic chemistry (J. McMurry: Organic Chemistry, 6th Ed. or equivalent) are considered as a prerequisite for attending the course. A student can be enrolled for Fundamentals of Chemistry of Pharmaceuticals after successful passing the entry test of organic chemistry. More details and a specimen entry test can be found at https://uoch.vscht.cz/studying/bc-subjects/fcp |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
Organic Chemistry B (B110002) or Organic Chemistry II (B110004) |
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Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
The exam is combined - the students have to successfully pass both a test and an oral part. |