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Fundamentals of Chemistry of Pharmaceuticals - S110026

Title:	Fundamentals of Chemistry of Pharmaceuticals
Guaranteed by:	Department of Organic Chemistry (110)
Faculty:	Faculty of Chemical Technology
Actual:	from 2016
Semester:	both
Points:	5
E-Credits:	5
Examination process:
Hours per week, examination:	3/0, Ex [HT]
Capacity:	winter:unknown / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
For type:
Additional information:	http://předmět je vyučován pouze v letním semestru
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment you can enroll for the course in winter and in summer semester

Guarantor:	Hampl František doc. Ing. CSc. Holakovský Roman Mgr. Ph.D. Kundrát Ondřej Ing. Ph.D.
Pre-requisite :	{x}
Interchangeability :	Z110026

Examination dates Schedule

Annotation -

Last update: Kubová Petra Ing. (23.05.2016)

The aim of the lectures is to bring basic information in the chemistry of pharmaceuticals which should help the alumni to start their professional career in pharmaceutical industry (R&D, manufacture, Regulatory&Compliance etc.) and in the drug distribution. The introductory lectures cover general pharmaceutical chemistry: basic terms and definitions, primciples of mutual drug and organism interactions, drug design methods, registration of drugs, and good manufacturing practice. The main part of the lectures is devoted to a brief survey of structures and syntheses of the most frequently used drugs.

Aim of the course -

Last update: Kubová Petra Ing. (23.05.2016)

Students will be:

able to know basic therapeutic groups of drugs

able to know the pharmacophores of the most frequently used drugs as well as the principles of their modes of action

able to know syntheses of the most frequently used drugs

informed on Regulatory&Compliance documentation for drug products (CTD Modul 3 - Quality) and will be able to participate in their preparation

Literature -

Last update: Kubová Petra Ing. (23.05.2016)

D: Vardanyan R., Hruby V. : Syntheses of Essential Drugs. Elsevier, 2006.

D: Patrick G. L. : An Introduction to Medicinal Chemistry. 3rd ed. Oxford University Press, Oxford 2005.

D: Kleemann A.; Engel J. Pharmaceutical Substances, Syntheses, Patents, Applications. 4th ed. Stuttgart : Thieme, 2001.

Learning resources -

Last update: Kubová Petra Ing. (23.05.2016)

http://eso.vscht.cz/

Requirements to the exam - Czech

Last update: Kubová Petra Ing. (23.05.2016)

Student se může přihlásit na zkoušku pouze v případě, že má složenou zkoušku z Organické chemie I (N110004) nebo Organické chemie B (N110029).

Syllabus -

Last update: Kubová Petra Ing. (23.05.2016)

1.Introduction. Basic terms and definitions.

2.Mutual drug and organism interactions. Basic terms in pharmacology.

3.Drug design methods. Registration of drugs. Good manufacturing practice.

4.Analgesics, antipyretics, anti-inflammatory agents.

5.Central nervous system drugs: anaesthetics, sedatives, hypnotics.

6.Central nervous system drugs: psychiatric drugs.

7.Autonomous nervous system drugs: sympathomimetics and sympatholytics.

8.Autonomous nervous system drugs: parasympathomimetics and parasympatholytics. Local anaesthetics and muscle relaxants.

9.Antihistamines and antiallergics. Antitussives and expectorants.

10.Cardiovascular system drugs.

11.Digestive tract therapeutic agents.

12.Antiinfective agents.

13.Chemotherapy of cancer.

14.Vitamins a hormones.

Entry requirements -

Last update: Kubová Petra Ing. (23.05.2016)

Fundamentals of Organic chemistry (J. McMurry: Organic Chemistry, 6th Ed. or equivalent) are considered as a prerequisite for attending the course. A student can be enrolled for Introduction into Chemistry of Pharmaceuticals after successful passing the entry test in organic chemistry.

Registration requirements -

Last update: Kubová Petra Ing. (23.05.2016)

Organic chemistry I, Pharmacology I.