Subjects

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Chemistry and Physics of Solid Pharmaceuticals - N108022

Title:	Chemie a fyzika pevných léčiv
Guaranteed by:	Department of Solid State Chemistry (108)
Faculty:	Faculty of Chemical Technology
Actual:	from 2008 to 2013
Semester:	both
Points:	3
E-Credits:	3
Examination process:
Hours per week, examination:	2/0, Ex [HT]
Capacity:	winter:126 / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	you can enroll for the course in winter and in summer semester

Guarantor:	Kratochvíl Bohumil prof. RNDr. DSc.

Examination dates Schedule

Annotation -

The course is focused on acquiring knowledge of chemistry and physics of solid pharmaceutical substances. Emphasis is placed on the study of the internal structure of substances (molecular and crystal) and the resulting macroscopic properties (solubility, dissolution rate, stability, degradation). The phenomena of polymorphism of pharmaceutical substances and processes of crystallization and dissolution are discussed in detail. Attention is paid to chemical and physical types of pharmaceutical substances (anhydrates, salts, hydrates, co-crystals) and their crystalline and amorphous forms. Last but not least, the focus is on the degradation products produced in pharmaceutical substances during production and during storage.

Last update: Kratochvíl Bohumil (13.02.2018)

Aim of the course -

Students will gain knowledge about:

internal structure of pharmaceutical substances (crystalline and molecular)

they will learn to orient themselves in the processes of crystallization and dissolution of pharmaceutical substances

will be able to apply and categorize the phenomenon of polymorphism in pharmacies

to orient among solid forms of pharmaceutical substances (anhydrate, hydrates, salts, co-crystals and amorphous)

to estimate possible degradation processes that occur in solid pharmaceutical substances

Last update: Kratochvíl Bohumil (13.02.2018)

Literature -

R:Hilfiker R.(Ed.), Polymorphism in the Pharmaceutical Industry, Wiley-VCH Verlag, Weinheim, Germany, 2006, 9783527311460

Last update: Kratochvíl Bohumil (13.02.2018)

Syllabus -

1. API Selection Criteria for Solid Drug Forms

2. Crystal structure

3. Molecular Crystal

4. Crystallization

5. Solubility and dissolution

6. Shape and particle size

7. Polymorphism

7. Anhydrates, hydrates, salts, co-crystals

8. Amorphous and semicrystalline forms

9. Physical (polymorphic) transformations, examples

10.Chemical degradation in solid phase

11.Oxidation, hydrolysis, dehydration, dehalogenation, decarboxylation, deamidation, denitrogenation

12.Fotodegradation

13.Polymerization, cyclization, epimerization, isomerization

14.Hygroscopicity

Last update: Kratochvíl Bohumil (13.02.2018)

Learning resources -

lectures for the course: https://uchpel.vscht.cz/studium/studijni_materialy

Last update: Kratochvíl Bohumil (13.02.2018)

Registration requirements -

Organic chemistry I, II

Fundamentals of Pharmacology

Last update: Kratochvíl Bohumil (13.02.2018)

Teaching methods
	Activity	Credits	Hours
	Konzultace s vyučujícími	0.5	14
	Účast na přednáškách	1	28
	Příprava na zkoušku a její absolvování	1.5	42
		3 / 3	84 / 84

Coursework assessment
Form	Significance
Oral examination	100