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The aim of this course is introduction of the disconnection approach to organic synthesis. This approach is analytical: we start with the molecule we want to make (the target molecule) and break it down by a series of disconnections into possible starting materials. During the course, the retrosynthetic method is shown on simple as well as on more complicated structures which are known from practical life: pharmaceuticals, pesticides, dyes, perfumes etc. Last update: Kundrát Ondřej (24.01.2018)
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It is compulsory to prepare project on the synthesis of natural compound, to pass written examination test with the result at least 60%, and finally to pass successfuly the oral examination. Last update: Kundrát Ondřej (15.02.2018)
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R: Warren S., Wyatt P.: Organic synthesis - The disconnection approach, 2nd Edition, John Wiley, 2008, 9780470712368
A: Warren S., Wyatt P.: Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition, John Wiley, 2009, 9780470712276
A: Wyatt P., Warren S.: Organic Synthesis - Strategy and Control, John Wiley, 2007, 9780470489405 Last update: Kundrát Ondřej (24.01.2018)
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1. The disconnection approach. Basic principles. 2. Oxidation states of organic compounds. 3. One group C-X disconnections. 4. Two group C-X disconnections. 5. One group C-C disconnections: alcohols. 6. One group C-C disconnections: carbonyl compounds. 7. Alkene and alkyne synthesis. 8. Two group disconnections. 1,3- and 1,5-difunctionalised compounds. 9. Two group disconnections. 1,2-, 1,4- and 1,6-difunctionalised compounds. 10. Strategy of ring synthesis. Baldwin's rules. 3-, 4- and 5-membered rings. 11. Six-membered rings. 12. Heterocycles. 13. Stereoselective synthesis. 14. Linear and convergent synthesis. Last update: Kundrát Ondřej (15.02.2018)
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Organic Synthesis Last update: Kundrát Ondřej (24.01.2018)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Účast na přednáškách | 1.5 | 42 | ||
| Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1.5 | 42 | ||
| Práce na individuálním projektu | 0.5 | 14 | ||
| Příprava na zkoušku a její absolvování | 2 | 56 | ||
| Účast na seminářích | 0.5 | 14 | ||
| 6 / 6 | 168 / 168 | |||
| Coursework assessment | |
| Form | Significance |
| Examination test | 50 |
| Oral examination | 50 |