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Emphasis is put on the theory and application of modern separation processes in the chemical and pharmaceutical industry. Students gain a background suitable for design, control and intensification of separation processes. The course embraces elements of chemical engineering, physical chemistry, mathematics and analytical chemistry. The understanding of preparative liquid chromatography and adsorption processes is supported by including lessons focused on adsorption theory and determination of adsorption isotherms.
Last update: Čapek Pavel (14.02.2018)
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Studenti musí úspěšně napsat 3 zápočtové testy a následně uspět u ústní zkoušky. Last update: Patera Jan (21.02.2018)
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R: J. D. Seader, E. J. Henley: Separation Process Principles, 2nd edition, John Wiley & Sons, New York (2006), 0470481838. A: R. B. Bird, W. E. Stewart, E. N. Lightfoot: Transport Phenomena, 2nd edition, John Wiley & Sons, New York (2007), 0470115394. A: R. C. Reid, J. M. Prausnitz, B. E. Poling: The Properties of Gases & Liquids, 4th edition, McGraw-Hill, Boston (1987), 0470115394. A: D. M. Ruthven: Principles of Adsorption and Adsorption Processes, John Wiley & Sons, New York (1984), 0471866067. A: R. Taylor, R. Krishna: Multicomponent Mass Transfer, John Wiley & Sons, New York (1993), 0471574171. Last update: Čapek Pavel (16.08.2024)
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two/three written tests and oral examination Last update: Kubová Petra (04.01.2018)
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Syllabus 1. Introduction and the course justification Specific position of small-scale technologies in chemical industry, features of pharmaceutical processes, scale-up in engineering of pharmaceutical processes, design and optimization of batch processes, more complex cases of process development 2. Material and Enthalpy Balances Rules for formulation of balances, derivation of equations, a typical apparatus - a column with the counter-current flow of phases, solution of equations 3. Liquid Extraction (Solvent Extraction) Solvent selection, types of extractors, process design, mass balance, solutions of non-linear equations, a case study 4. Solid -- Liquid Extraction (Leaching, Percolation, Infusion) Definition (mechanism, process methods), examples of applications, types of extractors, process design, mass balance, numerical solution of non-linear equations, process control, an example of calculation 5. Supercritical Extraction Definition, thermodynamic basis, types of extractors, process design, process control, industrial applications 6. Liquid Chromatography Introduction and definitions, classification, techniques (methods), equipment, stationary and mobile phases 7. Adsorption Definitions and basic quantities, Gibbs adsorption isotherm, models of adsorption isotherms, multicomponent adsorption isotherms, estimation of isotherm parameters 8. Preparative Liquid Chromatography Models of chromatographic columns, process design, equilibrium data acquisition 9. Adsorption Processes Microporous adsorbents, basic characteristics of the processes, cyclic batch systems (CBS), desorption (regeneration) methods for CBS, continuous countercurrent systems (CCS), comparison of chromatographic processes and CCS 10. Freeze Drying (Lyophilization) Introduction, benefits of freeze drying, freezing, freeze drying, rates of freeze drying, process equipment 11. Membranes and Mass Transfer Introduction, fundamentals, principles of membrane processes, mass transfer in membranes, types of membranes 12. Membrane Separation Processes Types of membrane processes, preparation and membrane module construction, concentration polarisation and membrane fouling 13. Crystallisation Basic definitions, phase equilibrium, basic balances, formation of nuclei, kinetics of crystal growth, hydrodynamic properties of suspensions, control of crystal shape, product properties, methods of crystallisation, sublimation and desublimation 14. Crystallisers classification of crystallisers, design of crystallisers Last update: Kubová Petra (04.01.2018)
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The lecturer provides students with copies of lectures in the PDF format on request. Last update: Kubová Petra (04.01.2018)
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Students will be able to: 1. Develop mass and energy balances of separation apparatuses. 2. Analyse and optimise separation processes in chemical and pharmaceutical industry. 3. Design a suitable approach for scaling up a process from the laboratory to production scale. Last update: Kubová Petra (23.02.2018)
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chemical engineering, physical chemistry, analytical chemistry, mathematics and basic programming in MATLAB Last update: Kubová Petra (04.01.2018)
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Mathematics I Physical Chemistry I Unit Operations of Chemical Engineering I Last update: Čapek Pavel (14.02.2018)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.4 | 10 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1 | 28 | ||
Práce na individuálním projektu | 0.1 | 4 | ||
Příprava na zkoušku a její absolvování | 1.5 | 42 | ||
Účast na seminářích | 1 | 28 | ||
5 / 5 | 140 / 140 |
Coursework assessment | |
Form | Significance |
Regular attendance | 10 |
Report from individual projects | 10 |
Continuous assessment of study performance and course -credit tests | 40 |
Oral examination | 40 |