Students will be able to:

1. Develop mass and energy balances of separation apparatuses.

2. Analyse and optimise separation processes in chemical and pharmaceutical industry.

3. Design a suitable approach for scaling up a process from the laboratory to production scale.

Studenti budou umět:

1. Formulovat látkové a energetické bilance separačních aparátů.

2. Analyzovat a optimalizovat separační procesy v chemickém a farmaceutickém průmyslu.

3. Přenést návrh separačního pochodu z laboratorního do průmyslového měřítka.

Studenti musí úspěšně napsat 3 zápočtové testy a následně uspět u ústní zkoušky.

R: J. D. Seader, E. J. Henley: Separation Process Principles, 2nd edition, John Wiley & Sons, New York (2006), 0470481838.

A: R. B. Bird, W. E. Stewart, E. N. Lightfoot: Transport Phenomena, 2nd edition, John Wiley & Sons, New York (2007), 0470115394.

A: R. C. Reid, J. M. Prausnitz, B. E. Poling: The Properties of Gases & Liquids, 4th edition, McGraw-Hill, Boston (1987), 0470115394.

A: D. M. Ruthven: Principles of Adsorption and Adsorption Processes, John Wiley & Sons, New York (1984), 0471866067.

A: R. Taylor, R. Krishna: Multicomponent Mass Transfer, John Wiley & Sons, New York (1993), 0471574171.

Z: J. Hanika: Speciální separační procesy, skripta VŠCHT, Praha (1998), 80-7080-242-1.

Z: J. D. Seader, E. J. Henley: Separation Process Principles, 2nd edition, John Wiley & Sons, New York (2006), 0470481838.

D: R. B. Bird, W. E. Stewart, E. N. Lightfoot: Transport Phenomena, 2nd edition, John Wiley & Sons, New York (2007), 0470115394.

D: R. C. Reid, J. M. Prausnitz, B. E. Poling: The Properties of Gases & Liquids, 4th edition, McGraw-Hill, Boston (1987), 0470115394.

D: D. M. Ruthven: Principles of Adsorption and Adsorption Processes, John Wiley & Sons, New York (1984), 0471866067.

D: R. Taylor, R. Krishna: Multicomponent Mass Transfer, John Wiley & Sons, New York (1993), 0471574171.

two/three written tests and oral examination

Tři zápočtové testy, které všechny musí být hodnoceny alespoň 17 body ze 40 možných. Ústní zkouška.

Syllabus

1. Introduction and the course justification

Specific position of small-scale technologies in chemical industry, features of pharmaceutical processes,

scale-up in engineering of pharmaceutical processes, design and optimization of batch processes, more complex

cases of process development

2. Material and Enthalpy Balances

Rules for formulation of balances, derivation of equations, a typical apparatus - a column with

the counter-current flow of phases, solution of equations

3. Liquid Extraction (Solvent Extraction)

Solvent selection, types of extractors, process design, mass balance, solutions of non-linear equations, a

case study

4. Solid -- Liquid Extraction (Leaching, Percolation, Infusion)

Definition (mechanism, process methods), examples of applications, types of extractors, process design, mass

balance, numerical solution of non-linear equations, process control, an example of calculation

5. Supercritical Extraction

Definition, thermodynamic basis, types of extractors, process design, process control, industrial applications

6. Liquid Chromatography

Introduction and definitions, classification, techniques (methods), equipment, stationary and mobile phases

7. Adsorption

Definitions and basic quantities, Gibbs adsorption isotherm, models of adsorption isotherms, multicomponent

adsorption isotherms, estimation of isotherm parameters

8. Preparative Liquid Chromatography

Models of chromatographic columns, process design, equilibrium data acquisition

9. Adsorption Processes

Microporous adsorbents, basic characteristics of the processes, cyclic batch systems (CBS), desorption

(regeneration) methods for CBS, continuous countercurrent systems (CCS), comparison of chromatographic

processes and CCS

10. Freeze Drying (Lyophilization)

Introduction, benefits of freeze drying, freezing, freeze drying, rates of freeze drying, process equipment

11. Membranes and Mass Transfer

Introduction, fundamentals, principles of membrane processes, mass transfer in membranes, types of membranes

12. Membrane Separation Processes

Types of membrane processes, preparation and membrane module construction, concentration polarisation and

membrane fouling

13. Crystallisation

Basic definitions, phase equilibrium, basic balances, formation of nuclei, kinetics of crystal growth,

hydrodynamic properties of suspensions, control of crystal shape, product properties, methods of

crystallisation, sublimation and desublimation

14. Crystallisers

classification of crystallisers, design of crystallisers

1. Úvod, charakteristika předmětu

2. Bilance, rovnovážné patro, fázové rovnováhy

3. Extrakce kapalina - kapalina

4. Extrakce tuhá fáze - kapalina (vyluhování)

5. Superkritická extrakce

6. Kapalinová chromatografie

7. Adsorpce

8. Preparativní kapalinová chromatografie

9. Adsorpční procesy

10. Mrazové sušení (lyofilizace)

11. Membrány a přenos hmoty

12. Membránové separační procesy

13. Krystalizace

14. Krystalizátory

The lecturer provides students with copies of lectures in the PDF format on request.

Přednášející poskytuje na požádání kopie přednášek v elektronickém formátu (PDF).

chemical engineering, physical chemistry, analytical chemistry, mathematics and basic programming in MATLAB

chemické inženýrství, fyzikální chemie, analytická chemie, matematika, základy programováni v MATLABu

Mathematics I

Physical Chemistry I

Unit Operations of Chemical Engineering I

Chemické inženýrství I

Fyzikální chemie I

Matematika I