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The course Organic Chemistry of Selected Elements fills the gap between the Organic Chemistry course and the course Transition Metals in Organic Synthesis. It is targeted on properties, preparation and reactions of the compounds of specific 2nd period elements (organoboron and organofluorine chemistry), as well as of 3rd period elements (organosilicon, organophosphorus and organosulfur chemistry). Attention is also paid to structures and reaction mechanisms of both hard (organolithium, organomagnesium), and soft (organocuprates) organometallic compounds.
Last update: Kvíčala Jaroslav (11.03.2014)
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Students will be able to: evaluate properties, synthesis and reactivity of organoboron compounds evaluate properties, synthesis and reactivity of organofluorine compounds evaluate properties, synthesis and reactivity of organoelement compounds of 3rd period (silicon, phosphorus and sulfur) evaluate properties, synthesis and reactivity of hard (organolithium and organomagnesium) and soft (organocopper) organometals Last update: Cibulka Radek (19.08.2013)
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R: Suzan E. Thomas: Organic Synthesis. The Roles of Boron and Silicon. Oxford University Press, Oxford 1991. R: M. Hudlický a A. Pavlath, ed.: Chemistry of Organic Fluorine Compounds II. ACS, Washington 1992. R: Gordon H. Whitham: Organosulfur Chemistry. Oxford University Press, Oxford 1991. R:D.J.H. Smith: Phosphorus Chemistry; Comprehensive Organic Chemistry, Vol. 5, D. Barton and W.D. Ollis, ed., str. 1119-1329. Pergamon Press, Oxford 1979. Last update: Cibulka Radek (28.08.2013)
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1. Overview of organic chemistry of 2nd row elements. 2. Properties and syntheses of organoboron compounds, hydroboration. 3. Reduction and homologation with organoboron compounds, boranes in neutron capture therapy, carboranes. 4. Properties of organofluorine compounds, introduction of fluorine, trifluoromethyl, perfluoroalkyl. 5. Fluorinated building blocks, applications of organofluorine compounds. 6. Principles of bonding in organic compounds of 3rd row elements, comparison with 2nd row elements. 7. Preparations and properties of organosilicon compounds. 8. Applications or organosilicon compounds, silicones. 9. Preparations and properties of organophosphorus compounds. 10. Applications of organophosphorus compounds, Wittig and Mitsunobu reactions. 11. Preparations and properties of organosulfur compounds. 12. Applications of organosulfur compounds, sulfur ylides, Julia reaction. 13. Preparations, properties and applications of organoselenium compounds. 14. Preparations, properties and applications of organolithium and organomagnesium compounds, organocuprates. Last update: Kvíčala Jaroslav (28.01.2008)
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Electronic version of lectures Last update: Kvíčala Jaroslav (14.08.2013)
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General and Inorganic Chemistry I, Organic Chemistry I Last update: Kvíčala Jaroslav (14.08.2013)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Účast na přednáškách | 1 | 28 | ||
| Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
| Příprava na zkoušku a její absolvování | 1.5 | 42 | ||
| 3 / 3 | 84 / 84 | |||
| Coursework assessment | |
| Form | Significance |
| Examination test | 40 |
| Continuous assessment of study performance and course -credit tests | 20 |
| Oral examination | 40 |