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The aim of the course is to acquaint students with polymeric systems for targeted drug delivery to specific sites in the body, with various routes of administration, with ligands for specific targeting of these systems, with the design of their structure and synthesis. The systems for sustained or timed release of active ingredients and systems enabling to bypass some undesirable properties of drugs will be described. Students will study both the systems that are already used in clinical practice and those that are only in various stages of clinical testing or just in basic research. The systems described will be divided according to the structure (the water-soluble polymers, polymer conjugates of proteins, liposomes, nanoparticles, hybrid stimuli-responsive systems), purpose (e.g. targeted cancerostatics, contraceptive implants vectors for gene therapy) and active ingredients (a chemotherapeutic agent, a protein, a nucleic acid, a radionuclide).
Last update: Fialová Jana (24.04.2020)
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Students will be able to: describe the most important macromolecular systems for targeted drug delivery and controlled drug release, they will learn the methods of their synthesis and eventual practical applications. Last update: Fialová Jana (24.04.2020)
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prezentation of scientific paper, oral exam Last update: Fialová Jana (24.04.2020)
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R:Glen S. Kwon, ed.: Polymeric Drug Delivery Systems (Drugs and the Pharmaceutical Sciences), Taylor and Francis Group, Boca Raton 2005. R:Ijeoma F. Uchegbu, Andreas G. Schatzlein, eds.: Polymers in Drug Delivery, Taylor and Francis Group, Boca Raton 2006. R:T. Prnka, K. Šperlink: Bionanotechnologie, nanobiotechnologie, nanomedicína, Repronis, Ostrava, 2006, ISBN 80-7329-134-7. http://www.nanotechnologie.cz/view.php?cisloclanku=2007080009 A:Hest, J. C. M. van. Biosynthetic-Synthetic Polymer Conjugates. Polym. Rev. 2007, 47, 63-92. A:Magnusson, J. P.; Saeed, A. O.; Fernández-Trillo, F.; Alexander, C. Synthetic Polymers for Biopharmaceutical Delivery. Polym. Chem. 2011, 2, 48. A:Zhou, Y.; Kopeček, J. Biological Rationale for the Design of Polymeric Anti-Cancer Nanomedicines. J. Drug Target. 2013, 21, 1-26. A:Liu, S.; Maheshwari, R.; Kiick, K. L. Polymer-Based Therapeutics. Macromolecules 2009, 42, 3-13. Last update: Fialová Jana (24.04.2020)
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1. History of polymer drug 2. Polymer drug carriers with various structure 3. Active and passive targeting of polymer drugs 4. Polymer cancerostatics 5. Selection and binding of targeting ligands 6. Solid phase peptide synthesis 7. Polymers in gene therapy 8. Covalent versus non-covalent methods of binding proteins to polymers 9. Polymer drugs in clinical trials and clinical practice Last update: Fialová Jana (24.04.2020)
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