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The course Organic Chemistry of Selected Elements fills the gap between the Organic Chemistry course and the course Transition Metals in Organic Synthesis. It is targeted on properties, preparation and reactions of the compounds of specific 2nd period elements (organoboron and organofluorine chemistry), as well as of 3rd period elements (organosilicon, organophosphorus and organosulfur chemistry). Attention is also paid to structures and reaction mechanisms of both hard (organolithium, organomagnesium), and soft (organocuprates) organometallic compounds.
Last update: Kubová Petra (14.10.2019)
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Students will be able to: evaluate properties, synthesis and reactivity of organoboron compounds evaluate properties, synthesis and reactivity of organofluorine compounds evaluate properties, synthesis and reactivity of organoelement compounds of 3rd period (silicon, phosphorus and sulfur) evaluate properties, synthesis and reactivity of hard (organolithium and organomagnesium) and soft (organocopper) organometals Last update: Kubová Petra (14.10.2019)
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The subject is completed by an exam consisting of written and oral part. A student is qualified for a final exam after giving a presentation on a selected topic. Last update: Rybáčková Markéta (17.09.2023)
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A: Suzan E. Thomas: Organic Synthesis. The Roles of Boron and Silicon. Oxford University Press, Oxford 1991. A: M. Hudlický a A. Pavlath, ed.: Chemistry of Organic Fluorine Compounds II. ACS, Washington 1992. A: Gordon H. Whitham: Organosulfur Chemistry. Oxford University Press, Oxford 1991. A: D.J.H. Smith: Phosphorus Chemistry; Comprehensive Organic Chemistry, Vol. 5, D. Barton and W.D. Ollis, ed., str. 1119-1329. Pergamon Press, Oxford 1979.
R: E. Fernández a A. Whiting, Ed., Synthesis and Applications of Organoboron Compounds, Topics in Organometallic Chemistry 49, Springer 2015, ISBN 978-3-319-13053-8. R. T. Hiyama, M. Oestreich, Ed., Organosilicon Chemistry: Novel Approaches and Reactions, Wiley 2019, ISBN 978-3-527-34453-6. R: V. Prakash Reddy, Organofluorine Chemistry. Synthesis and Applications. Elsevier 2020, ISBN 978-0-128-13286-9. R: V. Iaroshenko, Organophosphorus Chemistry: From Molecules to Applications. Wiley 2019, ISBN 978-3-527-67224-0. Last update: Kubová Petra (09.01.2020)
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1. Overview of organic chemistry of 2nd row elements. 2. Properties and syntheses of organoboron compounds, hydroboration. 3. Reduction and homologation with organoboron compounds, boranes in neutron capture therapy, carboranes. 4. Properties of organofluorine compounds, introduction of fluorine, trifluoromethyl, perfluoroalkyl. 5. Fluorinated building blocks, applications of organofluorine compounds. 6. Principles of bonding in organic compounds of 3rd row elements, comparison with 2nd row elements. 7. Preparations and properties of organosilicon compounds. 8. Applications or organosilicon compounds, silicones. 9. Preparations and properties of organophosphorus compounds. 10. Applications of organophosphorus compounds, Wittig and Mitsunobu reactions. 11. Preparations and properties of organosulfur compounds. 12. Applications of organosulfur compounds, sulfur ylides, Julia reaction. 13. Preparations, properties and applications of organoselenium compounds. 14. Preparations, properties and applications of organolithium and organomagnesium compounds, organocuprates. Last update: Kubová Petra (14.10.2019)
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Electronic version of lectures Last update: Kubová Petra (14.10.2019)
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No. Last update: Kubová Petra (14.10.2019)
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