Subjects

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Chemistry of Heterocyclic Compounds - D110012

Title:	Chemie heterocyklických sloučenin
Guaranteed by:	Department of Organic Chemistry (110)
Faculty:	Faculty of Chemical Technology
Actual:	from 2011 to 2022
Semester:	winter
Points:	winter s.:0
E-Credits:	winter s.:0
Examination process:	winter s.:
Hours per week, examination:	winter s.:0/0, other [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	course is intended for doctoral students only can be fulfilled in the future

Guarantor:	Kozmík Václav Ing. CSc.

Examination dates Schedule

Annotation -

The Lectures on Chemistry of heterocyclic compounds aim to introduce the preparation and reactivity of various simple heterocyclic compounds to the students. Based on the knowledge of the reactivity of heterocyclic compounds they should be able to design a synthesis of heterocyclic systems with a help of chemical literature and databases.

Last update: Kozmík Václav (11.04.2014)

Aim of the course -

Students will be able to:

describe the reactivity of basic heterocycles

depict syntheses of the basic heterocycles

suggest a synthesis of complicated heterocyclic systems using literature

Last update: Kozmík Václav (10.04.2014)

Course completion requirements -

Students have to propose a synthesis of two or three complicated heterocyclic compounds according to the assignment and present and defend it in front of the lecturer and students of this lecture.

Last update: Kozmík Václav (25.04.2014)

Literature -

R: Theophil Eicher, Siegfried Hauptmann: The Chemistry of Heterocycles (Structure, Reactions, Syntheses and Applications), Georg Thieme Verlag Stuttgart, New York 1995, ISBN 0865776253, 9780865776258

A: Alan R. Katritzky, Alexander F. Pozharskii: Handbook of Heterocyclic Chemistry, Second edition 2000, Pergamon 2000,ISBN 0080429890, 9780080429892

Last update: Kozmík Václav (10.04.2014)

Syllabus -

1. Trivial and Hantzsch - Widman nomenclature of simle heterocyclus.

2. Nomenclature and numbering of heterocyclic systems. Examples.

3. Synthesis and properties of 3-membered heterocycles.

4. Synthesis and properties of 4-membered heterocycles.

5. Synthesis and properties of 5-membered heterocycles with 1 heteroatoms.

6. Synthesis and properties of 5-membered heterocycles with 2 heteroatoms.

7. Synthesis and properties of 5-membered heterocycles with 3 and more heteroatoms.

8. Synthesis and properties of 6-membered heterocycles with 1 heteroatoms.

9. Synthesis and properties of 6-membered heterocycles with 2 heteroatoms.

10. Synthesis and properties of 6-membered heterocycles with 3 and more heteroatoms.

11. Synthesis and properties of 7 and more membered heterocycles.

12. Generalization of nucleophilic and electrophilic substitutions and metallation reactions.

13. Generalization of addition and cycloaddition reactions.

14. Biological activity of heterocycles.

Last update: Kozmík Václav (11.04.2014)

Learning resources -

Václav Kozmík: Heterocyklické sloučeniny, http://uoch.vscht.cz/cz/download/Heterocyklicke_slouceniny.pdf

Last update: Kozmík Václav (10.04.2014)

Coursework assessment
Form	Significance
Defense of an individual project	20
Examination test	50
Oral examination	30