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The course is focused on principles of operation of unit operations employed in pharmaceutical industry in solid dosage form manufacturing. The course require the student to have the general understanding of the typical equipment used for processing the dispersion systems comprising the particulate solids, such as hoppers, classification or separation systems, blenders, mills, granulators, compactors or tablet presses. The course will extend this general knowledge by the detailed explanation of the physical aspects of the particulate solid processing in the equipment above, and methods of design and optimization thereof. Students will get the insight into the mechanisms and principles at the level required for mathematical modeling such systems.
Last update: Pátková Vlasta (19.04.2018)
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Students will be able to: Describe key principles of selected unit operations including their underlying principles Establish quantitative relationships between parameters and behavior/outputs of unit operations Solve model problems of optimization of selected manufacturing processes Last update: Zámostný Petr (18.10.2018)
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Working out 6 of 7 project tasks and preparing protocols. Last update: Zámostný Petr (03.05.2022)
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R: Hickey A. J., Ganderton D: Pharmaceutical Process Engineering, Marcel Dekker (2001) or Hickey A. J., Ganderton D: Pharmaceutical Process Engineering 2ed., Marcel Dekker (2016). R: Rhodes M: Introduction To Particle Technology, John Wiley & Sons Ltd. (2008). A: Schultze D.: Powders and bulk solids, 2ed., Springer (2021). A: Muzzio F.J. et al.: Solids Mixing in Handbook of Industrial Mixing, pp. 1333-1351, John Wiley and Sons (2004) A: Parikh D.M. ed.: Handbook of Pharmaceutical Granulation Technology 4ed, Taylor & Francis Group, LLC (2021). Last update: Zámostný Petr (15.11.2022)
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lectures, preparation of project oriented on identifying current challenges and solutions related to selected unit operation Last update: Zámostný Petr (18.10.2018)
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The course is specifically oriented on: 1. Characteristics and characterization of particles and particulate systems 2. Mechanics of flow of particulate solids 3. Mixing, segregation, and separation of particulate solids 4. Principles of particle fragmentation, comminution processes 5. Wet agglomeration processes 6. Compaction physics of particulate solids 7. Roll-compaction 8. Tablet compression Last update: Zámostný Petr (18.10.2018)
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Supplementary course materials available via university network Last update: Zámostný Petr (18.10.2018)
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