Subjects

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Engineering in the Pharmaceutical Industry - AB111012

Title:	Engineering in the Pharmaceutical Industry
Guaranteed by:	Department of Organic Technology (111)
Faculty:	Faculty of Chemical Technology
Actual:	from 2022
Semester:	winter
Points:	winter s.:5
E-Credits:	winter s.:5
Examination process:	winter s.:
Hours per week, examination:	winter s.:3/0, Ex [HT]
Capacity:	unlimited / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Additional information:	http://předmět vyučován pouze v zimním semestru
Note:	course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	Patera Jan Ing. Ph.D. Zámostný Petr prof. Ing. Ph.D.
Interchangeability :	B111012, N111014

Examination dates

This subject contains the following additional online materials

E-learning course

Annotation -

The course provides knowledge of the preparation of dosage forms, which are crucial for the formulation of pharmaceutical products. Principles of liquid, semi-solid and solid dosage forms and methods for assessing their quality are explained, using chemical engineering principles and knowledge of physical chemistry and other disciplines. Particular attention is paid to particulate solids, their storage, transport, mixing, granulation and tabletting. Biotech synthesis of antibiotics in aerobic digesterare are discussed separately.

Last update: Kubová Petra (16.04.2018)

Aim of the course -

Students will be able to:

Apply theoretical knowledge to specific processes used in industry.

Apply theoretical knowledge on research of processes of pharmaceutical industry, including biotechnology synthesis of antibiotics.

Analyze and combine the basic operational processes of manufacture of dosage forms in the pharmaceutical industry.

Acquire basic analytical methods for the evaluation of solid dosage forms according to the Czech Pharmacopoeia.

Last update: Kubová Petra (16.04.2018)

Course completion requirements - Czech

Studenti musí napsat zkouškový test na více než 50 % bodů a uspět u ústní zkoušky.

Last update: Kubová Petra (16.04.2018)

Literature -

Obligatory:

Introduction to Particle Technology, Rhodes M., Seville J., 2024

Pharmaceutical Process Engineering, Hickey A.J., Ganderton D., 2009

Recommended:

Pharmaceutical process scale up, Levin M., 2011

Last update: Patera Jan (14.08.2024)

Requirements to the exam - Czech

1. Písemná zkouška

2. Ústní zkouška

Last update: Kubová Petra (16.04.2018)

Syllabus -

1. Dosage forms, classification.

2. Solid materials, characteristics, classification.

3. Crushing, milling, storage and transport of solids Handling of solids, mixing, size reduction.

4. Homogenization, technology, equipment.

5. Wet granulation, technology, equipment. Pressure compaction of solids.

6. Drugs formulation, solid dosage forms, methods of quality assessment.

7. Solid dosage forms, tablettes, capsules and their manufacturing.

8. Semi solid formulations.

9. Extraction, liquid dosage forms.

10. Basic principles of sterilization.

11. Theory of fermentation processes, growth law for micro-organism population.

12. Bioreactors for aerobic processes.

13. Fermentation control, micro-organism separation.

14. Separation processes, filtration, lyophilization.

Last update: Kubová Petra (16.04.2018)

Learning resources -

https://e-learning.vscht.cz/course/view.php?id=408

Last update: Kubová Petra (16.04.2018)

Entry requirements - Czech

Pro zápis tohoto předmětu je nutno mít minimálně zapsán předmět N409002

Last update: Kubová Petra (16.04.2018)

Registration requirements -

Unit Operations of Chemical Engineering I

Physical Chemistry I

Last update: Kubová Petra (16.04.2018)