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The course covers basic aspects of physical chemistry, which are used in drug research and production, and further deepens knowledge of state behavior and thermodynamic properties of pure liquids and solids, thermodynamic description of condensed solutions, phase and chemical equilibria in heterogeneous systems, physical chemistry of surfaces and phase interfaces. and macrokinetic description of phase transformations and chemical reactions. There is also a section devoted to the influence of the size and shape of nanostructured materials on their physical and chemical properties, which is one of the modern trends in recent years in drug development. The content of the course is mainly focused on pharmaceutically important substances and systems and processes commonly used in the manufacture of drugs.
Last update: Školáková Tereza (03.05.2022)
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Students will be able to: Derive and explain basic thermodynamic relations. Interpret phase diagrams of different systems. Understand the principles of phase transformations. Solve problems related to the processes and events at phase interfaces. Last update: Školáková Tereza (03.05.2022)
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Acquiring credit for solving examples of the computational part. Successful completion of the test (at least 40%) and passing the oral exam. Last update: Školáková Tereza (03.05.2022)
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1. Connors, K. A., Mecozzi, S. (2010). Thermodynamics of pharmaceutical systems: An introduction to theory and applications. John Wiley & Sons. ISBN: 978-0-470-56751-7 2. Leitner, J., Sedmidubský, D., Voňka, P. (2019) Termodynamika materiálů (skripta VŠCHT), 2. vydání, VŠCHT Praha. ISBN: 978-80-7592-045-4 3. Otto, D. P., de Villiers, M. M. (2009). Physicochemical principles of nanosized drug delivery systems. In Nanotechnology in drug delivery (pp. 3-33). Springer, New York, NY. ISBN: 978-0-387-77668-2 Last update: Školáková Tereza (03.05.2022)
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1. Basic thermodynamic terminology and principles 2. Structure and bonding in solids 3. State behaviour of liquids and solids 4. Thermodynamic functions of pure liquids and solids 5. Thermodynamic concept of equilibrium 6. Phase transformations phase equilibria in single-component systems 7. Chemical transformations with the participation of pure liquids and solids 8. Thermodynamics of solutions 9. Phase and chemical equilibria with the participation of liquid and solid solutions 10. Surfaces and phase interfaces 11. Porosity of solid materials. 12. Kinetics of chemical and phase transformations 13. Influence of particles size and shape on the properties of solids 14. Heterogeneous dispersions Last update: Školáková Tereza (03.05.2022)
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Physical Chemistry I Last update: Školáková Tereza (03.05.2022)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Konzultace s vyučujícími | 0.5 | 14 | ||
| Účast na přednáškách | 1 | 28 | ||
| Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
| Příprava na zkoušku a její absolvování | 1.5 | 42 | ||
| Účast na seminářích | 0.5 | 14 | ||
| 4 / 4 | 112 / 112 | |||