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The aim of the course is to acquaint students in detail with the representatives of individual groups of pathogenic or conditionally pathogenic microorganisms (bacteria, viruses, fungi and parasites), with their influence on human health and also with the mechanisms and pathogenesis of these microorganisms. Attention will be paid to the tropism, principles of the host colonization and the subsequent pathogenesis of the microorganisms. Diseases, caused by the individual microorganisms and approaches to their treatment will be described. Attention will also be paid to toxins and their mode of actions, mechanisms of action of antimicrobial compounds, but also to the emergence of resistance. The defense against pathogenic microorganisms due to vaccinations will be discussed too. Students will also become acquainted with the problematics of human microbiome and the impact of its composition and changes on the human health. Modern microbiological diagnostic methods will also be described.
Last update: Ulbrich Pavel (27.07.2018)
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Students will understand the problematics of microorganisms causing various diseases, as well as the mechanisms of their actions on humans. They will be able to distinguish between the representatives of human microbiome and pathogenic microorganisms. They will also know and be able to describe the diseases caused by pathogenic microorganisms, to identify these microorganisms and propose the approaches to their elimination. Students will understand not only the mechanisms of action of toxins of selected microorganisms and their pathogenesis in general, but also the actions of antimicrobial agents and emerging resistance. They will also understand the vaccination problematics. Last update: Ulbrich Pavel (27.07.2018)
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The course ends with written and oral part of the exam. Last update: Ulbrich Pavel (27.07.2018)
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R: Murray P., Rosenthal K., Pfaller M.: Medical microbiology, 8th Edition; Elsevier, 2015. ISBN 9780323299565 R: Goering R., Dockrell H., Zuckerman M., Roitt I., Chiodini P.: Mims´Medical Microbiology, 5th Edition; Elsevier, 2013. ISBN 9780723436010 A: Ryan K.: Sherris Medical Microbiology, 7th Edition; McGraw-Hill Education, 2018. ISBN 9781259859809 Last update: Ulbrich Pavel (27.07.2018)
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Lectures of teachers with active participtaion of students. Last update: Ulbrich Pavel (27.07.2018)
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none Last update: Ulbrich Pavel (27.07.2018)
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First part of the course will be focused on human microbiome and its role in human health. Then the lectures will proceed with the topics on common principles of pathogenicity and virulence of microorganisms. Tropism and collonization of the host. Toxins, toxoids. Vaccination. Antibiotics, antivirotics, antifungals, chemotherapeutics, principles of micoorganisms resistance. The main part of our course will be focused on the pathogenicity of following microorganisms: Spirochetes, Gram-positive cocci, Gram-negative cocci and coccobacilli, Gram-positive non-spore forming and sporulating aerobic rods, anaerobic bacteria, non Gram-staining bacteria, Mollicutes, Chlamydia, non spore-forming aerobic bacteria, Gram-positive aerobic spore-forming rods, aerobic gram-negative rods, facultative anaerobic gram-negative rods, Gram-negative aerobic to microaerophilic rods, Rickettsia, fungi, protozoa, viruses - DNA and RNA viruses, viroids, virophages, prions. Finally, we will describe the principles of modern methods of the detection of pathogenic microorganisms.
Last update: Ulbrich Pavel (27.07.2018)
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http://textbookofbacteriology.net/ http://microbewiki.kenyon.edu/index.php/MicrobeWiki https://www.nature.com/ismej.index.html https://scholar.google.com/ Last update: Ulbrich Pavel (27.07.2018)
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none Last update: Ulbrich Pavel (27.07.2018)
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Basics of microbiology, biology and biochemistry. Last update: Ulbrich Pavel (29.06.2018)
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