|
|
|
||
Last update: Fialová Jana (24.04.2020)
|
|
||
Last update: Fialová Jana (24.04.2020)
Students will be able to: describe the reactivity of basic heterocycles depict syntheses of the basic heterocycles suggest a synthesis of complicated heterocyclic systems using literature |
|
||
Last update: Fialová Jana (24.04.2020)
R: Theophil Eicher, Siegfried Hauptmann: The Chemistry of Heterocycles (Structure, Reactions, Syntheses and Applications), Georg Thieme Verlag Stuttgart, New York 1995, ISBN 0865776253, 9780865776258 A: Alan R. Katritzky, Alexander F. Pozharskii: Handbook of Heterocyclic Chemistry, Second edition 2000, Pergamon 2000,ISBN 0080429890, 9780080429892 |
|
||
Last update: Fialová Jana (24.04.2020)
Václav Kozmík: Heterocyklické sloučeniny, http://uoch.vscht.cz/cz/download/Heterocyklicke_slouceniny.pdf |
|
||
Last update: Fialová Jana (24.04.2020)
1. Trivial and Hantzsch - Widman nomenclature of simle heterocyclus. 2. Nomenclature and numbering of heterocyclic systems. Examples. 3. Synthesis and properties of 3-membered heterocycles. 4. Synthesis and properties of 4-membered heterocycles. 5. Synthesis and properties of 5-membered heterocycles with 1 heteroatoms. 6. Synthesis and properties of 5-membered heterocycles with 2 heteroatoms. 7. Synthesis and properties of 5-membered heterocycles with 3 and more heteroatoms. 8. Synthesis and properties of 6-membered heterocycles with 1 heteroatoms. 9. Synthesis and properties of 6-membered heterocycles with 2 heteroatoms. 10. Synthesis and properties of 6-membered heterocycles with 3 and more heteroatoms. 11. Synthesis and properties of 7 and more membered heterocycles. 12. Generalization of nucleophilic and electrophilic substitutions and metallation reactions. 13. Generalization of addition and cycloaddition reactions. 14. Biological activity of heterocycles. |
|
||
Last update: Fialová Jana (24.04.2020)
Students have to propose a synthesis of two or three complicated heterocyclic compounds according to the assignment and present and defend it in front of the lecturer and students of this lecture. |