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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
Students will be able to: characterize basic properties of an organic substance develop chromatographic methods for characterization and purification of substances using achiral and chiral stationary phases utilize chromatographic methods in hyphenation with mass spectrometry to identify organic substances determine the structure of organic compounds using spectroscopic methods
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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
Williams D.H., Fleming I.: Spectroscopic methods in organic chemistry. 6. edition. ISBN-13: 978-0077118129
Richards S.A., Hollerton J.C.: Essential Practical NMR for Organic Chemistry, 2011 John Wiley & Sons, ISBN: 978-0-470-71092-0 https://onlinelibrary.wiley.com/doi/book/10.1002/9780470976401
Meyer V.R.: Practical High-Performance Liquid Chromatography, 5. edition, Wiley 2010, ISBN-13: 978-0470682173 |
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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470988749
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118647042
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527611737
https://onlinelibrary.wiley.com/doi/book/10.1002/9780471980582
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118120187
https://onlinelibrary.wiley.com/doi/book/10.1002/0471690082
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527654703
https://onlinelibrary.wiley.com/doi/book/10.1002/0470079096
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527611973
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527809202
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470516898
https://onlinelibrary.wiley.com/doi/book/10.1002/0471736589
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470395813 |
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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
1.Methods of structural analysis in characterization of biologically active substances 2.Identification of unknown substances: sample preparation and design of experiment 3.Basic properties of substances by means of thin layer chromatography 4.Introduction to high-performance liquid chromatography, screening in normal and reversed phase 5.Preparative chromatography in normal and reversed phase – method development 6.Special chromatographic modes – HILIC, ion-exchange, multimodal stationary phases 7.Supercritical fluid chromatography and its application in pharmaceutical industry 8.Chiral stationary phases, their applications and limitations in analysis and purification of drugs 9.Preparative chiral separation – method development 10.Liquid chromatography hyphenated to mass spectrometry 11.Identification of compound structure by NMR spectroscopy 12.Determination of absolute configuration of enantiomers by means of chiroptic methods 13.Structure determination of an unknown substance 14.Presentation of the determination of the unknown structure |
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Last update: Kohout Michal prof. Ing. Ph.D. (23.05.2022)
To finish the subject, it is required to present a method for determination of the unknow sample structure. |