Student will be able to:

apply chemical engineering methods to biological processes

describe kinetics of biomass and product formation

describe quantitatively and design a simple bioreactor - chemostat

Z: Shuler M. L., Kargi F., Bioprocess Engineering. Basic Concepts, Prentice Hall, Upper Saddle River, 2002, 0-13-081908-5

D: Doran P., Bioprocess Engineering Principles, Academic Press, 1995, New York, 9780122208553

1. Introduction to the studies. Engineering and biological access to problem solving (production penicillin).

2. Basic piece of knowledge from cellulate biology.

3. Enzymes: classification, molecular structure, common characteristics and characteristics of enzymes.

4. Enzyme system kinetics, kinetic models, determination of kinetic parameters.

5. Immobilization of enzymes and microbial cells, used techniques and methods.

6. Transport processes in systems with immobilize enzymes. Manufacturing of enzymes, application of enzymes.

7. Simulation of kinetics microbial growth and performance metabolites, stoichiometry.

8. Influence of cultural conditions on kinetics of growth microbial cells.

9. Cellular growth and performance metabolites in batch cultures.

10. Cellular growth and performance metabolites in continuous cultures.

11. Fermenters, selection cultural method, bath and continuous bioreactors.

12. Simulation of fermenters, immobilize microbial cell, fermentation solid - state. Transmission masses.

13. Scale-up criteria, running and drive bioreactors. Simulation of bioreactors.

14. Aeration, sterilization.

see recommended literature

Unit operations of Chemical Engineering I