SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Transition Metals in Organic Synthesis - AM110005
Title: Transition Metals in Organic Synthesis
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:6
E-Credits: winter s.:6
Examination process: winter s.:
Hours per week, examination: winter s.:3/1 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Dvořák Dalimil prof. Ing. CSc.
Tobrman Tomáš doc. Ing. Ph.D.
Annotation
Last update: Kundrát Ondřej Ing. Ph.D. (24.01.2018)
Reactions based on the chemistry of transition metals play an important role both in the chemical industry and in the organic synthesis. This course is divided into two parts. In the first part the students familiarize themselves with basic principles of the chemistry of transition metals, with the reactions in coordination sphere and with chemical properties of common ligands. The second part deals with an application of this chemistry in some important industrial processes and especially in the organic synthesis.
Literature
Last update: Kundrát Ondřej Ing. Ph.D. (24.01.2018)

L. S. Hegedus: Transition Metals in the Synthesis of Complex Organic Molecules (University Science Books, Sausalito, California, 1999), 1891389041

Syllabus -
Last update: Kundrát Ondřej Ing. Ph.D. (15.02.2018)

1. Formalism (oxidation state, d-electron configuration, 18-electron rule).

2. Basic types of ligands (s-complexes).

3. Basic types of ligands (p-complexes).

4. Reactions in coordination sphere of transition metals (ligand substitution, oxidative addition, reductive elimination, insertion, transmetallation).

5. Nucleophilic attack on ligands coordinated to transition metals.

6. Electrophilic attack on ligands coordinated to transition metals.

7. Homogeneous catalytic reactions (hydrogenation, hydrosilation, hydrocyanation, alkene and alkyne polymerisation, carbonylation reactions).

8. Synthetic applications of transition metal hydrides, organocuprates.

9. Synthetic applications of complexes from insertion of alkenes and alkynes.

10. Synthetic applications of complexes from oxidative addition followed with insertion of alkene, alkyne and carbon monoxide (cross coupling, Heck reaction).

11. Synthetic applications of transition metal carbonyl complexes.

12. Synthetic applications of transition metal carbene complexes (reactions of nucleophilic and electrophilic carbenes, alkene metathesis, metal-catalysed decomposition of diazo compounds).

13. Synthetic applications of h3-allyl transition metal complexes.

14. Synthetic applications of transition metal h6-arene complexes (Cr(CO)3 and FeCp+ complexes).

Registration requirements
Last update: Kundrát Ondřej Ing. Ph.D. (15.02.2018)

Organic Synthesis, Organic Reaction Mechanisms

Course completion requirements
Last update: Kundrát Ondřej Ing. Ph.D. (16.02.2018)

Successful passing of two seminar tests and oral exam.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1,5 42
Příprava na zkoušku a její absolvování 4 112
Účast na seminářích 0,5 14
6 / 6 168 / 168
Coursework assessment
Form Significance
Continuous assessment of study performance and course -credit tests 50
Oral examination 50

 
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