SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Bioengineering Methods - AM409010
Title: Bioengineering Methods
Guaranteed by: Department of Chemical Engineering (409)
Faculty: Faculty of Chemical Engineering
Actual: from 2021
Semester: summer
Points: summer s.:4
E-Credits: summer s.:4
Examination process: summer s.:
Hours per week, examination: summer s.:2/1, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Slouka Zdeněk doc. Ing. Ph.D.
Interchangeability : M409010, N409057, S409057
Is interchangeable with: M409010
Annotation -
The course is building on the basic knowledge of chemical engineering by the student and develops applications in bioengineering. Basic approaches including mass and energy balances, transport processes and reaction kinetics are synthesized to provide quantitative description of processes used in bioengineering. Special attention is given to reaction-transport processes in enzyme reactors and reactors with living cultures of microorganisms.
Last update: Kubová Petra (22.01.2018)
Aim of the course -

Students will be able to:

apply quantitative approaches of chemical engineering to biosystems

design basic types of enzyme reactors and bioreactors

design suitable unit operations for modification of inlets and outles from the bioreactor

Last update: Kubová Petra (22.01.2018)
Literature -

R: Shuler M. L. , Kargi F., DeLisa M., Bioprocess Engineering: Basic Concepts, 3rd Edition, Prentice Hall 2017, ISBN-13: 9780132901451

A: Doran P., Bioprocess Engineering Principles - 2nd Edition, Academic press 2012, ISBN: 9780122208515, 9780080917702

A: Villadsen J., Lee S.Y., Nielsen J., Stephanopoulos G. (eds.), Fundamental Bioengineering, Wiley-Blackwell, 2016, ISBN: 978-3527336746.

Last update: Schreiber Igor (12.11.2018)
Learning resources -

lecture notes available at

Last update: Kubová Petra (22.01.2018)
Syllabus -

1. Enzyme catalysis, thermodynamics of enzyme reactions, limitin cases

2. Enzyme reactors, mathematical models and their analysis

3. Immobilized enzymes, effects of mass transport

4. Effectiveness factor, Damköhler number, analysis of heterogeneous enz. systems

5. Microbial growth, stoichiometry of growth, product formation

6. Growth in batch systems

7. Growth in continual systems

8. Structured vs unstructured models of growth

9. Construction and operation of some fermentor types

10. Stirring and aeration

11. Mixed microbial cultures and their interaction

12. Chemostat dynamics with mixed cultures

13. Operating conditions, scale-up

14. Metabolic engineering, metabolic networks

Last update: Kubová Petra (22.01.2018)
Registration requirements -

Unit operations of chemical engineering I and II

Last update: Kubová Petra (22.01.2018)
Course completion requirements -

Student must pass two tests during the course of semester (minimum 25 points out of 50 for each test).

Last update: Schreiber Igor (30.05.2019)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 0.5 14
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