SubjectsSubjects(version: 912)
Course, academic year 2022/2023
  
Biotechnology in pharmacy - AP319009
Title: Biotechnology in pharmacy
Guaranteed by: Department of Biotechnology (319)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2022
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0, other [HT]
Capacity: winter:unlimited / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Masák Jan prof. Ing. CSc.
Annotation
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)
Advanced biotechnological processes for the industrial production of pharmaceutical preparations or their precursors. Biochemical and engineering nature of these processes, their regulation, and control. An overview of biotechnologies used to obtain important drugs.
Aim of the course
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)

Students will know the advanced biotechnological processes used in the industrial production of various types of pharmaceuticals; they will understand the nature of biosynthesis and its control in different types of producers; they be able to compile a theoretical design of a technological process for the production of a compound; they gain a comprehensive overview of the production of pharmaceuticals using biotechnological processes.

Literature
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)

R: Murray Moo-Young (Ed.) Comprehensive Biotechnology 3rd edition, Pergamon 2019.

A: D. J. A. Crommelin et.al. Pharmaceutical Biotechnology 4th edition, Springer 2013.

A: B. H. Lee. Advanced Fermentation and Cell Technology, Wiley Blackwell 2022.

Learning resources
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)

https://onlinelibrary-wiley-com.ezproxy.vscht.cz/doi/book/10.1002/14356007

Syllabus
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)

1. Introduction - the participation of biotechnological processes in the pharmaceutical industry

2. Development of biological agents for biotechnology - microorganisms, tissue cultures, higher eukaryotes

3. Modification and regulation of metabolism to achieve high drug overproduction

4. Characteristics of unit operations of downstream and upstream processes in biotechnology

5. Biotechnological production of polyketides

6. Biotechnological production of other antibiotics

7. Biotechnological production of anticancer drugs

8. Biotechnological production of pharmaceutically important alkaloids and other toxins

9. Biotechnological production of vitamins

10. Biotechnological production of polysaccharides

11. Therapeutic enzymes

12. Industrial biotransformations for the production of precursors and products in pharmacy

13. Vaccines

14. Other biopharmaceuticals

Course completion requirements
Last update: Masák Jan prof. Ing. CSc. (12.05.2022)

Successful completion of the oral exam.

 
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