SubjectsSubjects(version: 880)
Course, academic year 2020/2021
Counterfeits of medicines, drugs and cosmetics - AP402018
Title: Counterfeits of medicines, drugs and cosmetics
Guaranteed by: Department of Analytical Chemistry (402)
Actual: from 2019
Semester: summer
Points: summer s.:0
E-Credits: summer s.:0
Examination process: summer s.:
Hours per week, examination: summer s.:2/1 other [hours/week]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: doctoral
Note: can be fulfilled in the future
Guarantor: Setnička Vladimír prof. Ing. Ph.D.
Urban Štěpán prof. RNDr. CSc.
Sýkora David doc. Dr. RNDr.
Interchangeability : P402018
Annotation -
Last update: Pátková Vlasta (16.11.2018)
The subject is focused on methods of advanced analytical chemistry, which are able to recognize small differences in chemical composition, differences in structure and thus can identify counterfeits of pharmaceuticals, cosmetics, foodstuffs, etc. In addition to well-known separation methods with mass detection that allow detailed chemical analysis of trace impurities, emphasis will be placed on special experimental techniques that allow to specify the origin of compounds in the samples or to distinguish different ways of their preparation. These are analytical methods that are both able to specify the chiral composition of samples and determine the degree of chiral purity, or methods that are capable of studying weak inter-molecular interactions, thereby providing information on the various manufacturing processes, especially for solid samples. Examples of these special techniques are spectroscopy of vibrational circular dichroism, Raman optical activity, electronic circular dichroism, imaging methods, terahertz and far infrared spectroscopy, and last but not least, various chiral and multidimensional separations. Part of the course will be experimental practical exercises in special laboratories.
Aim of the course -
Last update: Pátková Vlasta (16.11.2018)

Students will be acquainted with special methods of advanced analytical chemistry with a focus on forensic applications, where, besides detailed analysis of molecular composition, the subject of study will also be the interaction between molecules and molecular systems, including the manifestations of optical activity. Students will acquire knowledge about the theoretical background of spectroscopic and separation methods, available instrumentation, measurement methodology and data evaluation in counterfeit detection. Enantiomeric purity analysis, absolute configuration, molecular conformation, adulterant presence, sample aging monitoring, counterfeit production / preparation, etc. will also be demonstrated. Students also participate in practical demonstrations of measurements in special laboratories.

Literature -
Last update: Jahoda Milan doc. Dr. Ing. (29.11.2018)

A: S.L. Dexheimer, Ed. Terahertz Spectroscopy, CRC Press, Boca Raton, 2008.

A: M.C. McMaster, LC/MS, John Wiley and Sons, Hoboken, 2005.

A: N. Berova, K. Nakanishi, P. L. Polavarapu and R. W. Woody, eds., Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules, John Wiley & Sons Inc., Hoboken, New Jersey, 2012.

A: M. Urbanová, P. Maloň, Circular Dichroism Spectroscopy v Analytical Methods in Supramolecular Chemistry (Schalley C. A., Ed.), Wiley VCH: Weinheim, Germany, Second Edition, 2012, str. 337-369.ISBN: 978-3-527-32982-3.

Teaching methods -
Last update: Pátková Vlasta (16.11.2018)

Lectures of various specialists and practical demonstrations of measurements in special laboratories.

Syllabus -
Last update: Pátková Vlasta (16.11.2018)

1) Definitions of counterfeit and imitation, legislation. Possibilities of chemical investigation of counterfeits.

2) Basic analytical methods for counterfeiting detection.

3) Separation methods and their use in counterfeit analysis.

4) Specification of liquid, gas chromatography and electro-migration methods. Application of preparative chromatography.

5) Elemental analysis, AAS, ICP-MS, ESCA.

6) Methods of molecular spectroscopy, their division, and applications in counterfeit detection.

7) Vibrational spectroscopy methods, the study of weak interactions by vibrational spectroscopy.

8) Terahertz spectroscopy. Study of polymorphism and crystallinity.

9) Chiroptic spectroscopy, VCD, ROA, ECD.

10) Mass spectrometry and its use in counterfeit analysis.

11) Portable instruments of chemical analysis and their practical use.

12) Methods of chemical data evaluation, sophisticated databases utilization.

13) Practical Examples I.

14) Practical examples II.

Registration requirements -
Last update: Jahoda Milan doc. Dr. Ing. (29.11.2018)

Molecular Spectroscopy

Separation methods

Recommended: Special Spectroscopic Techniques

Course completion requirements -
Last update: Pátková Vlasta (16.11.2018)