SubjectsSubjects(version: 899)
Course, academic year 2021/2022
  
Chemistry and Physics of Solid Pharmaceuticals - B108005
Title: Chemie a fyzika pevných léčiv
Guaranteed by: Department of Solid State Chemistry (108)
Actual: from 2021
Semester: both
Points: 3
E-Credits: 3
Examination process:
Hours per week, examination: 2/0 Ex [hours/week]
Capacity: winter:unlimited / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Bachelor's
Note: you can enroll for the course in winter and in summer semester
Guarantor: Kratochvíl Bohumil prof. RNDr. DSc.
Interchangeability : N108022
Annotation -
Last update: Kubová Petra Ing. (03.01.2018)
The lecture is focused on providing general knowledge of chemistry and physics of pharmaceutical solids. Great emphasis is put on the crystal structure and the resulting properties of drugs. Very important phenomenon of polymorphism and solid forms of active pharmaceutical substances (anhydrates, hydrates, salts, cocrystals) are discussed in more details. Chemical and physical degradation processes and products of solid API are also mentioned.
Aim of the course -
Last update: Kratochvíl Bohumil prof. RNDr. DSc. (09.01.2018)

Students will be able to:

understand the internal structure and arrangement of crystal and amorphous phases of solid pharmaceutical ingredients (API)

knowledgeable in polymorphism of anhydrates, hydrates, salts, cocrystals

predict possible degradation processes and products of solid API‘s

Literature -
Last update: Kratochvíl Bohumil prof. RNDr. DSc. (09.01.2018)

R:Hilfiker R.(Ed.), Polymorphism in the Pharmaceutical Industry, Wiley-VCH Verlag, Weinheim, Germany, 2006, 9783527311460

Learning resources -
Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)

https://uchpel.vscht.cz/studium/studijni_materialy

Syllabus -
Last update: Kratochvíl Bohumil prof. RNDr. DSc. (09.01.2018)

1. Introduction to pharmaceutical solids

2. Crystal and amorphous phases

3. Molecular solids

4. Crystallization

5. Solubility and dissolution

6. Phenomenon of polymorphism

7. Examples of polymorphic systems

7. Solid forms of API’s (anhydrates, hydrates, salts, cocrystals)

8. Amorphous pharmaceutical phases

9. Size a shape of particles

10. Microstructure of dosage forms

11. Degradation processes in solids, stability tests

12. Photodegradation

13. Hygroscopicity

14. Patents

Registration requirements -
Last update: Kratochvíl Bohumil prof. RNDr. DSc. (13.02.2018)

Organic chemistry I, II

Fundamentals of Pharmacology

 
VŠCHT Praha