SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Trends in Drug Research and Development - B111011
Title: Výzkum a vývoj léčiv
Guaranteed by: Department of Organic Technology (111)
Faculty: Faculty of Chemical Technology
Actual: from 2020
Semester: summer
Points: summer s.:3
E-Credits: summer s.:3
Examination process: summer s.:
Hours per week, examination: summer s.:2/0, C+Ex [HT]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Zbytovská Jarmila doc. Mgr. Dr. rer. nat.
Interchangeability : N111045
This subject contains the following additional online materials
Annotation -
The subject presents the particular periods of the drug discovery process from searching for active structures to clinical testing. Emphasis is placed on the mutual relationships between biological activity of drugs, their chemical structures and physico-chemical properties.
Last update: Zbytovská Jarmila (11.01.2018)
Aim of the course -

Students will be able to:

  • understand issues of the structure-activity relationships of drugs
  • apply the basic QSAR principles
  • characterise drug's life inside the organism using enlarged knowledge in pharmacokinetics
  • understand issues of drug discovery

Last update: Hladíková Jana (03.01.2018)
Literature -

R: Kuchař M.: Výzkum a vývoj léčiv. Vydavatelství VŠCHT Praha, 2008. ISBN 978-80-7080-677-7

A: Tsaioun K., Kates S.: ADMET for Medicinal Chemists: A Practical Guide. Wiley 2011. ISBN 978-0470484074

A: Hartl J., Palát K.: Farmaceutická chemie I. Karolinum 2011. ISBN 978-80-246-2033-6

A: Smith D. van den Waterbeemd H., Walker D.: Pharmacokinetics and metabolism in drug design. Wiley 2006. ISBN 3-527-31368

Last update: Hladíková Jana (03.01.2018)
Learning resources -

Learning materials distributed by lecturer

Last update: Hladíková Jana (03.01.2018)
Syllabus -

1) A historical overview of drug discovery

2) The drug development process, preclinical and clinical testing

3) Current trends in drug discovery, biologics, management of drug research and development

4) Development of generic drugs, relationships between original and generic companies

5, 6) Modifications of drug structures, structure-activity relationships

7) The LADME model, pharmacokinetics

8) Pharmacodynamics, Drug-receptor interactions

9, 10) Physico-chemical properties of drugs and their parametrization

11, 12) QSAR and its practical impacts, regression analysis, QSAR descriptors

13) Interpretation of regression relationships, dependent and independent variables, collinearity of parameters, selection of structure changes

14) Current QSAR approaches, the CoMFA method, similarity models, lead structures identification, molecular modelling

Last update: Zbytovská Jarmila (11.01.2018)
Registration requirements -

Pharmacology I, Introduction into Chemistry of Pharmaceuticals

Last update: Hladíková Jana (03.01.2018)
Course completion requirements - Czech

Studenti musí vypracovat zadanou zápočtovou práci a napsat zkouškový test na více než 50 % bodů.

Last update: Zbytovská Jarmila (25.02.2018)
Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.3 8
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0.7 20
Příprava na zkoušku a její absolvování 1 28
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