Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
The course is focused on an influence of reaction conditions on progress of organic reactions and prediction of organic reaction mechanism based on basic priciples of organic chemistry.
Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
Předmět se zabývá vlivem reakčních podmínek na průběh organických reakcí a návrh reakčních mechanismů nových organických reakcí v souladu s poznatky moderní organické chemie.
Aim of the course -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
Students will be able to:
understand the mechanisms of substitution, elimination and addition reactions.
predict the course of reactions.
suggest suitable mechanism of novel organic reaction.
Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
Studenti budou umět:
Mechanismy základních organických reakcí
Navrhnout vhodný mechanismus problematické reakce
Zvolit vhodnou metodiku k prokázání navrženého mechanismu
Literature -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (24.04.2014)
R: Grossman R.B., The Art of Writing Reasonable Organic Reaction Mechanisms, New York, Springer, 2003, 9780387954684
R: Edenborough M., Organic Reaction Mechanisms, Taylor & Francis Ltd, London, 1999, 0748406417
A: Carey F.A., Sundberg R.J., Advanced Organic Chemistry, Springer, New York, 9780387683461
A: Smith M.B., March J., March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, John Wiley & Sons, New Jersey, 9780471720911
Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
Z:Grossman R.B., The Art of Writing Reasonable Organic Reaction Mechanisms, New York, Springer, 2003, 9780387954684
Z:Edenborough M., Organic Reaction Mechanisms, Taylor & Francis Ltd, London, 1999, 0748406417
D:Carey F.A., Sundberg R.J., Advanced Organic Chemistry, Springer, New York, 9780387683461
D:Smith M.B., March J., March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, John Wiley & Sons, New Jersey, 9780471720911
Syllabus -
Last update: Tobrman Tomáš doc. Ing. Ph.D. (10.04.2014)
1. General terms. Structural and electronic effects influencing a reaction course. Transition state theory.
2. Electrophilic substitution on sp3 hybridized carbon atom. Synthetic use and examples.
3. Nucleophilic substitution on sp3 hybridized carbon atom. Influence of neighboring group, nucleophile and leaving group in the reaction outcome and mechanism. Synthetic use and examples.
4. Electrophilic aromatic substitution. Synthetic use and examples. Evaluation of substituents on aromatic systems and their influence on the reaction course.
