SubjectsSubjects(version: 877)
Course, academic year 2020/2021
Unit Operations of Solid Dosage Form Manufacturing - D111025
Title: Jednotkové operace výroby pevných lékových forem
Guaranteed by: Department of Organic Technology (111)
Actual: from 2016
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:0/0 other [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
For type:  
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Zámostný Petr prof. Ing. Ph.D.
Z//Is interchangeable with: AP111004, P111004
Annotation -
Last update: Zámostný Petr prof. Ing. Ph.D. (24.02.2017)
The course is focused on principles of operation of unit operations employed in pharmaceutical industry in solid dosage form manufacturing. The course require the student to have the general understanding of the typical equipment used for processing the dispersion systems comprising the particulate solids, such as hoppers, classification or separation systems, blenders, mills, granulators, compactors or tablet presses. The course will extend this general knowledge by the detailed explanation of the physical aspects of the particulate solid processing in the equipment above, and methods of design and optimization thereof. Students will get the insight into the mechanisms and principles at the level required for mathematical modeling such systems.
Literature -
Last update: Kubová Petra Ing. (16.02.2017)

1. Hickey A. J., Ganderton D: Pharmaceutical Process Engineering, Marcel Dekker (2001).

2. Rhodes M: Introduction To Particle Technology, John Wiley & Sons Ltd. (2008).

3. Schultze D.: Powders and bulk solids, Springer (2008).

4. Muzzio F.J. et al.: Solids Mixing in Handbook of Industrial Mixing, pp. 1333-1351, John Wiley and Sons (2004)

5. Swarbrick J. ed.: Handbook of Pharmaceutical Granulation Technology, Taylor & Francis Group, LLC (2005).

Syllabus -
Last update: Kubová Petra Ing. (16.02.2017)

1. Characteristics and characterization of particles and particulate systems

2. Mechanics of flow of particulate solids

3. Mixing, segregation, and separation of particulate solids

4. Principles of particle fragmentation, comminution processes

5. Wet agglomeration processes

6. Compaction physics of particulate solids

7. Roll-compaction

8. Tablet compression