SubjectsSubjects(version: 908)
Course, academic year 2022/2023
Bioengineering - D319003
Title: Bioinženýrství
Guaranteed by: Department of Biotechnology (319)
Actual: from 2019
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:0/0, other [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
For type:  
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Halecký Martin doc. Ing. Ph.D.
Is interchangeable with: AP319001, P319001
Annotation -
Last update: Brányik Tomáš prof. Ing. Ph.D. (17.03.2014)
The characterization of biological processes catalyzed by enzymes or microbial cells is carried out by models including kinetic and mass balance equations. This course is therefore focused on creating mass and energy balances and their application in mathematical models describing the studied systems. These models of biological systems will be used to predict the behaviour of systems im limit cases and in scale-up (down) processes.
Aim of the course -
Last update: Brányik Tomáš prof. Ing. Ph.D. (17.03.2014)

Student will be able to:

Independently carry out mass balances of different biotechnological processes.

Extend the mass balances with kinetic equations describing the dynamic aspects of the system.

Estimate the key process parameters and by using them describe the scale-up (down) of bioprocesses.

Literature -
Last update: Brányik Tomáš prof. Ing. Ph.D. (17.03.2014)

Z - Lecture presentations

Z - Zlokarnik M. Scale-up in Chemical Engineering, Wiley-VCH, 2002, ISBN: 3-527-30266-2

Z - Levin M. (ed) Pharmaceutical Process Scale-up, Marcel Dekker Inc., 2001, ISBN: 0-8247-0625-0

D - Reisman H.B. Problems in scale-up of biotechnology production process, Critical Reviews in Biotechnology 13(3):195-253, 1993

Syllabus -
Last update: Brányik Tomáš prof. Ing. Ph.D. (17.03.2014)

The structure of bioprocesses, overview of equipment and unit operations.

The methods and procedure of biological processes modeling.

Mass and energy balancess.

Kinetics of enzymatic reactions and microbial growth.

Scale-up and scale-down of bioprocesses.

Criteria of scale-up, principles of similarity (geometric, kinetic, dynamic)

Dimensional analysis.

Registration requirements -
Last update: Brányik Tomáš prof. Ing. Ph.D. (17.03.2014)


Coursework assessment
Form Significance
Regular attendance 20
Defense of an individual project 20
Oral examination 60